NCT05400629

Effects of a 12-week Strength Training Program in Women With Myotonic Dystrophy Type 1

Completed NA Last updated 10 February 2023

What this trial tests

NA trial testing Training program in Myotonic Dystrophy 1 in 12 participants. Completed in 10 January 2023.

Timeline

1 January 2022

Primary endpoint
30 June 2022

10 January 2023

Quick facts

Lead sponsor	Université de Sherbrooke
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	supportive care
Enrollment	12
Start date	1 January 2022
Primary completion	30 June 2022
Estimated completion	10 January 2023
Sites	1 location across Canada

Drugs / interventions tested

• Training program

Conditions studied

• Myotonic Dystrophy 1 — all drugs for Myotonic Dystrophy 1 →

Sponsor

Université de Sherbrooke — full company profile →

Who can join

Adults 30 to 65, female only, with Myotonic Dystrophy 1. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

20 women with myotonic dystrophy type 1 (DM1) will complete a 12-week lower-limb strength training program. The training program consist of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg press, hip abduction, squat and plantar flexion. Training sessions will be closely supervise and take place twice a week. It is hypothesize that the training program will induce muscular hypertrophy despite the genetic defect. The training program should also have positive effects on function. The participants will be evaluated at baseline, week 6, week 12, month 6 and month 9 to quantify the effects of the training program and if these effects will be maintained over time.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1.
   Davey EE, Légaré C, Planco L, Shaughnessy S, et al · · 2023 · cited 13× · PMID 37318869 · DOI 10.1172/jci.insight.163856
2. Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1.
   Di Leo V, Lawless C, Roussel MP, Gomes TB, et al · · 2023 · cited 11× · PMID 37638448 · DOI 10.3233/jnd-230099
3. A 12-Week Strength Training Improves Mitochondrial Respiration, H<sub>2</sub>O<sub>2</sub> Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1.
   Marcangeli V, Girard-Côté L, Di Leo V, Roussel MP, et al · · 2025 · cited 1× · PMID 41241935 · DOI 10.1111/apha.70135
4. Effect of exercise training on clinical and physiological variables in adults with myotonic dystrophy type 1: a systematic review and meta-analysis.
   Shetty S, Luo Y, Thomas A, Gamil K, et al · · 2026 · PMID 41963558 · DOI 10.1007/s00415-026-13808-y