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NCT05395819: CERVASA
Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis
NA trial testing Reverse Total Shoulder Arthroplasty (RTSA) in Shoulder Osteoarthritis in 40 participants. Currently enrolling.
30 May 2026
Quick facts
| Lead sponsor | University of Alberta |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 30 May 2022 |
| Primary completion | 30 May 2026 |
| Estimated completion | 30 May 2026 |
| Sites | 8 locations across Canada |
Drugs / interventions tested
- Reverse Total Shoulder Arthroplasty (RTSA)
- Total Shoulder Arthroplasty (TSA)
Conditions studied
- Shoulder Osteoarthritis — all drugs for Shoulder Osteoarthritis →
Sponsor
University of Alberta
Who can join
65 and older, any sex, with Shoulder Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and it is common in an aging population. Surgical shoulder replacement (arthroplasty) is typically considered when non-surgical measures, such as physiotherapy or medication, have failed. There are two commonly performed surgical replacement procedures in patients who have advanced shoulder OA, and are 65 years of age and older: "Total Shoulder replacement or Arthroplasty (TSA)" and "Reverse Total Shoulder Arthroplasty (RTSA)". Few studies have compared the two procedures. Surgeons face uncertainty regarding which procedure to perform in patients 65 years of age and older. This pilot Randomized Controlled Trial (RCT) will compare the "TSA" and "RTSA" procedures, in patients 65 years of age and older. Participants will be assigned at random, (like flipping a coin), to one of the two groups (TSA or RTSA). The overall goal of this pilot study is to determine which procedure produces better functional and quality of life outcomes with fewer complications within the first 12-months after surgery. Moreover, pilot data will help determining the feasibility of conducting a larger trial comparing TSA versus RTSA surgical management in 65 years of age and older participants with advanced shoulder OA.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05395819
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Reverse Total Shoulder Arthroplasty (RTSA)
Trials testing the same drug.
- NCT04807322 — Reverse Total Shoulder Arthroplasty in Patients Who Exceeded Their Life-expectancy: a Retrospective Study · completed
Other recruiting trials for Shoulder Osteoarthritis
Currently open trials in the same condition.
- NCT07347054 — Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA) · NA · recruiting
- NCT06381791 — CBD for Pain Following Orthopedic Shoulder Surgery · Phase 1, PHASE2 · recruiting
- NCT06319911 — AETOS Shoulder System · recruiting
- NCT06025448 — Is MIO-RSA Noninferior to BIO-RSA When it Comes to Mechanical Implant Stability? · NA · recruiting
- NCT06025331 — Does BIO-RSA Provides Superior Clinical Outcome Compared to Conventional RSA? · NA · recruiting
Other University of Alberta trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05395819 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alberta
- Last refreshed: 30 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05395819.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing