Last reviewed · How we verify
NCT05388708: ASCEND
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
trial testing ECMO support in Acute Respiratory Distress Syndrome in 550 participants. Currently enrolling.
30 September 2027
Quick facts
| Lead sponsor | University of Michigan |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 550 |
| Start date | 4 February 2021 |
| Primary completion | 30 September 2027 |
| Estimated completion | 30 September 2027 |
| Sites | 99 locations across Italy, Colombia, New Zealand, Chile, Sweden, United Kingdom, Canada, Australia |
Drugs / interventions tested
- ECMO support
- PROSpect protocolized therapies
Conditions studied
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
- Extracorporeal Membrane Oxygenation — all drugs for Extracorporeal Membrane Oxygenation →
Sponsor
University of Michigan
Who can join
Adults 14 Days to 20, any sex, with Acute Respiratory Distress Syndrome or Extracorporeal Membrane Oxygenation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatric intensive care unit. The second objective is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Understanding clinical and biological heterogeneity to advance precision medicine in paediatric acute respiratory distress syndrome.
Kneyber MCJ, Khemani RG, Bhalla A, Blokpoel RGT, et al · · 2023 · cited 25× · PMID 36566767 · DOI 10.1016/s2213-2600(22)00483-0 -
ECMO-induced coagulopathy: strategic initiatives for research and clinical practice (a workshop report of the NHLBI).
Levy JH, Alexander PMA, Wolberg AS, McCarty OJT, et al · · 2025 · cited 11× · PMID 40766281 · DOI 10.1016/j.bvth.2025.100064 -
Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC.
Alexander PMA, Di Nardo M, Combes A, Vogel AM, et al · · 2024 · cited 7× · PMID 39299748 · DOI 10.1016/s2352-4642(24)00132-9
Verify or expand the search:
- PubMed search for NCT05388708
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Respiratory Distress Syndrome
Currently open trials in the same condition.
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- NCT06919484 — The Physiological Effect of RCexp on Ventilation/Perfusion Distribution · recruiting
- NCT07126964 — Extended Prone Positioning for Intubated ARDS · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05388708 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Michigan
- Last refreshed: 24 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05388708.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing