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NCT05387811: GLOBAL-AKI
International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
trial testing Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy in Liver Cirrhosis in 1,456 participants. Completed in 30 November 2023.
30 September 2023
Quick facts
| Lead sponsor | Azienda Ospedaliera di Padova |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,456 |
| Start date | 1 July 2022 |
| Primary completion | 30 September 2023 |
| Estimated completion | 30 November 2023 |
| Sites | 38 locations across Italy, Paraguay, Poland, South Korea, Denmark, Netherlands, Russia, Mexico |
Drugs / interventions tested
- Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy
Conditions studied
- Liver Cirrhosis — all drugs for Liver Cirrhosis →
- Acute Kidney Injury — all drugs for Acute Kidney Injury →
- Hepatorenal Syndrome — all drugs for Hepatorenal Syndrome →
Sponsor
Azienda Ospedaliera di Padova — full company profile →
Who can join
18 and older, any sex, with Liver Cirrhosis or Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aims of this study will be to identify the clinical characteristics, the management and the outcomes of acute kidney injury in patients with cirrhosis worldwide. Specific aims: 1. To establish the severity of AKI across different regions 2. To identify precipitants of AKI across different centers 3. To identify the phenotypes of AKI across different centers 4. To evaluate differences in the management of AKI across different centers and their impact on clinical outcomes 5. To assess outcomes of acute kidney injury (resolution of AKI, in-hospital mortality, 28-day mortality, 90-day mortality)
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study.
Patidar KR, Ma AT, Juanola A, Barone A, et al · · 2025 · cited 12× · PMID 40058397 · DOI 10.1016/s2468-1253(25)00006-8 -
Real-World Use of Terlipressin in Cirrhosis and Acute Kidney Injury: Frequent Use Beyond Hepatorenal Syndrome.
Ma AT, Juanola A, Patidar KR, Barone A, et al · · 2026 · cited 1× · PMID 40930302 · DOI 10.1016/j.cgh.2025.08.031
Verify or expand the search:
- PubMed search for NCT05387811
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Liver Cirrhosis
Currently open trials in the same condition.
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- NCT07418008 — The Liver Cirrhosis Cognitive Decline Scale (LiCCoS) · recruiting
- NCT07201649 — Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcificati · NA · recruiting
- NCT07252102 — Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients · NA · recruiting
Other Azienda Ospedaliera di Padova trials
Trials by the same sponsor.
- NCT07241676 — Early Recurrence After Surgery for Pancreatic Cancer · enrolling by invitation
- NCT07056972 — Surveillance Discontinuation in 5 Year Stable Trivial Branch Duct Intraductal Papillary Mucinous Neoplasms · not yet recruiting
- NCT07072143 — An International Study on Pediatric Patients With Rare Tumors. · recruiting
- NCT07241663 — Surgery for Locally Unresectable Pancreatic Cancer · recruiting
- NCT06720883 — Robotically Assisted Surgery For Perihilar Cholangiocarcinoma: A Prospective Study · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05387811 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliera di Padova
- Last refreshed: 30 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05387811.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing