Who is sponsoring NCT05386264?

NCT05386264 is sponsored by King's College Hospital NHS Trust.

What drugs are being tested in NCT05386264?

Interventions in NCT05386264: Expanded autologous T regulatory cells.

What condition does NCT05386264 study?

NCT05386264 studies Aplastic Anemia.

Is NCT05386264 still recruiting?

NCT05386264 is currently status unknown. Last updated 5 October 2023.

Last reviewed 2023-10-05 · How we verify

NCT05386264: TIARA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Autologous Tregs for Aplastic Anaemia

Status unknown Phase 1 Last updated 5 October 2023

What this trial tests

Phase 1 trial testing Expanded autologous T regulatory cells in Aplastic Anemia in 12 participants. Status unknown.

Timeline

14 July 2022

Primary endpoint
30 September 2024

30 April 2025

Quick facts

Lead sponsor	King's College Hospital NHS Trust
Phase	Phase 1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	12
Start date	14 July 2022
Primary completion	30 September 2024
Estimated completion	30 April 2025
Sites	1 location across United Kingdom

Drugs / interventions tested

Expanded autologous T regulatory cells

Conditions studied

Aplastic Anemia — all drugs for Aplastic Anemia →

Sponsor

King's College Hospital NHS Trust

Who can join

18 and older, any sex, with Aplastic Anemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This Phase I study will determine the safety and optimal dose of expanded autologous Tregs to treat patients with Aplastic Anaemia (AA) (who have failed, or are considered ineligible for IST (immunosuppressive therapy) / other treatments) using expanded autologous T regulatory cells (Tregs) from AA patients at King's College Hospital, that have been prepared at the licensed Good Manufacturing Practices (GMP) production facility at Guy's Hospital, London

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Protocol for a phase I single-centre dose escalation trial of autologous thymus derived regulatory T cells in paediatric heart transplant recipients to prevent cardiac allograft vasculopathy (ATT-Heart).
Aiyengar A, Fanelli G, Romano M, Patel P, et al · · 2026 · PMID 42167954 · DOI 10.1136/bmjopen-2025-108683

Verify or expand the search:

Other recruiting trials for Aplastic Anemia

Currently open trials in the same condition.

NCT07101770 — A Prediction Model in Pregnant Women With Aplastic Anemia · recruiting
NCT06752694 — Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult P · Phase 2 · recruiting
NCT06936930 — Reproductive and Mental Health of Patients With Aplastic Anemia · recruiting
NCT06689800 — Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy · NA · recruiting
NCT06613880 — Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia · Phase 2 · recruiting

Other King's College Hospital NHS Trust trials

Trials by the same sponsor.

NCT07384884 — Surgery and Laser Interstitial Thermal Therapy for Bilateral Glioblastomas · NA · not yet recruiting
NCT07379723 — Brief Intervention for FCD: A Feasibility Study · NA · recruiting
NCT07062731 — Pelvic Floor Exercises for Suboptimal Anorectal Manometry · recruiting
NCT06766162 — Virtual Reality to Improve Patient Experience During Endoscopic Mucosal and Submucosal Resection · NA · completed
NCT06918756 — Development of a Cough Control Questionnaire (CCQ) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05386264 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by King's College Hospital NHS Trust
Last refreshed: 5 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05386264.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing