NCT05382234

Multisystem Inflammatory Syndrome In Children at Sohag University Hospital

Status unknown Last updated 19 May 2022

What this trial tests

trial testing CBC, ESR ,CRP,Liver Function ,renal function ,ABG,Na,K,D-dimmer ,cardiac enzyme,ferritin ,blood and urine culture in negative cases in Multisystem Inflammatory Syndrome in Children in 50 participants. Status unknown.

Timeline

1 June 2022

Primary endpoint
1 June 2023

1 June 2023

Quick facts

Lead sponsor	Sohag University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	50
Start date	1 June 2022
Primary completion	1 June 2023
Estimated completion	1 June 2023
Sites	1 location across Egypt

Drugs / interventions tested

• CBC, ESR ,CRP,Liver Function ,renal function ,ABG,Na,K,D-dimmer ,cardiac enzyme,ferritin ,blood and urine culture in negative cases

Conditions studied

• Multisystem Inflammatory Syndrome in Children — all drugs for Multisystem Inflammatory Syndrome in Children →

Sponsor

Sohag University

Who can join

Adults 1 Day to 12, any sex, with Multisystem Inflammatory Syndrome in Children. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Since its initial description in December 2019 in Wuhan , China, Corona virus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has rapidly evolved into a worldwide pandemic affecting millions of lives .

Unlike adults, the vast majority of children with COVID-19 have mild symptoms. However, there are children who have significant respiratory disease, and some children may develop a hyper inflammatory response similar to what has been observed in adults with COVID-19. Furthermore, in late April 2020, reports emerged of children with a different clinical syndrome resembling Kawasaki disease (KD) and toxic shock syndrome; these patients frequently had evidence of prior exposure to SARS-CoV-2.

The pathophysiology of MIS-C:

Is unclear ,but it appears to be a consequence of a exacerbated immune system response or maladaptive response of the host .After the virus enters the human cells, the first line of defense against infection should be a quick and well-coordinated immune response ;however, when this mechanism is unregulated and excessive ,hyper inflammation can occur.

Cytokines that play an important role in inducing immunity and immunopathology during infections in excess can cause the clinical syndrome known as cytokine storm. The inflammatory response caused by SARS-CoV-2appears to be the major cause of mortality in infected patients .

The infection of dendritic cells or macrophages by SARS-CoV-2 induces the production of low levels of antiviral cytokines and increases the production of inflammatory cytokines (tumor necrosis factor\[TNF\], interleukin\[IL\]-1, IL-6,and interferon ).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.