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NCT05382208: DEPTH
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Phase 2 trial testing Doxycycline in Emphysema in 133 participants. Participants enrolled and being followed up; not accepting new ones.
1 February 2027
Quick facts
| Lead sponsor | Weill Medical College of Cornell University |
|---|---|
| Phase | Phase 2 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 133 |
| Start date | 22 August 2022 |
| Primary completion | 1 February 2027 |
| Estimated completion | 1 February 2027 |
| Sites | 20 locations across United States |
Drugs / interventions tested
- Doxycycline (doxycycline) — full drug profile →
- Placebo
Conditions studied
Sponsor
Weill Medical College of Cornell University
Who can join
30 and older, any sex, with Emphysema or HIV. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Rate of decline (slope) of percent predicted diffusing capacity for carbon monoxide (DLCO) corrected for hemoglobin, carboxyhemoglobin and barometric pressure (indicated as ppDLCOadj) over the 72 week treatment period.
Time frame: 72 weeks
Sponsor's own description
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of antibiotic-resistant bacterial infections.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
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Pathogenesis and management of emphysema in people with HIV.
Kreniske JS, Kaner RJ, Glesby MJ. · · 2023 · cited 2× · PMID 37848398 · DOI 10.1080/17476348.2023.2272702 -
Premature Aging of the Airway Epithelium in Chronic Obstructive Pulmonary Disease in People Living with HIV.
Kaner RJ. · · 2022 · cited 2× · PMID 35579631 · DOI 10.1164/rccm.202204-0743ed -
Pulmonary Immunocompromise in Human Immunodeficiency Virus Disease.
Attia EF, Maleche-Obimbo E, Ellington LE, North CM. · · 2025 · cited 1× · PMID 39890288 · DOI 10.1016/j.ccm.2024.10.014
Verify or expand the search:
- PubMed search for NCT05382208
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT07164131 — Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lacta · Phase 4 · recruiting
- NCT06915688 — A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations · NA · not yet recruiting
Other recruiting trials for Emphysema
Currently open trials in the same condition.
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- NCT06891755 — Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3 · NA · recruiting
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- NCT06533371 — Clinical-ultrasonographic Assessment of Pulmonary Emphysema · NA · recruiting
- NCT06528418 — Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath · recruiting
Other Weill Medical College of Cornell University trials
Trials by the same sponsor.
- NCT07485712 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 · NA · not yet recruiting
- NCT05811338 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 · NA · not yet recruiting
- NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
- NCT06818734 — Implementation of a Clinical Decision Support Tool for Postpartum Depression · NA · not yet recruiting
- NCT07485725 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 3 · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05382208 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Weill Medical College of Cornell University
- Last refreshed: 22 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05382208.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing