NCT05381025 is a NA clinical trial of Kava (Piper methysticum) extract in Sleep, sponsored by Thorne HealthTech, Inc.

Who is sponsoring NCT05381025?

NCT05381025 is sponsored by Thorne HealthTech, Inc.

What drugs are being tested in NCT05381025?

Interventions in NCT05381025: Kava (Piper methysticum) extract.

Is NCT05381025 still recruiting?

NCT05381025 is currently completed. Last updated 13 October 2022.

Last reviewed 2022-10-13 · How we verify

NCT05381025

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Kavalactones on Sleep and Cortisol in Healthy Special Forces Trainees

Completed NA Last updated 13 October 2022

What this trial tests

NA trial testing Kava (Piper methysticum) extract in Sleep in 15 participants. Completed in 9 October 2022.

Timeline

11 May 2022

Primary endpoint
1 July 2022

9 October 2022

Quick facts

Lead sponsor	Thorne HealthTech, Inc
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	other
Enrollment	15
Start date	11 May 2022
Primary completion	1 July 2022
Estimated completion	9 October 2022
Sites	1 location across United States

Drugs / interventions tested

Kava (Piper methysticum) extract

Conditions studied

Sleep — all drugs for Sleep →

Sponsor

Thorne HealthTech, Inc

Who can join

18 and older, male only, with Sleep. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research study is being done to better understand the effects of kava supplementation on sleep quality and salivary cortisol in the context of the acute physical and psychological stress of military special forces preparation training. Kava is a botanical dietary supplement derived from the plant Piper methysticum. Cortisol is a hormone associated with stress.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Kavalactones support motivation to move during intensive training in males preparing for military special operations forces.
Smith SY, Aylwin CF, Daniels TF, Greer JL, et al · · 2024 · PMID 39010683 · DOI 10.1080/15502783.2024.2377194

Verify or expand the search:

Other recruiting trials for Sleep

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NCT07213908 — Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth · NA · recruiting
NCT06670287 — The Use of Multiple Sensors to Track Sleep in Nightshift Workers · NA · recruiting

Other Thorne HealthTech, Inc trials

Trials by the same sponsor.

NCT05297032 — Effects of Quercetin on Metabolic Health · NA · terminated
NCT04026672 — Hemp Oil + User Experience Study · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05381025 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Thorne HealthTech, Inc
Last refreshed: 13 October 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05381025.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing