NCT05379920 is a NA clinical trial of High Volume Aerobic Exercise in Concussion, Brain, sponsored by State University of New York at Buffalo.

Who is sponsoring NCT05379920?

NCT05379920 is sponsored by State University of New York at Buffalo.

What drugs are being tested in NCT05379920?

Interventions in NCT05379920: High Volume Aerobic Exercise, Low Volume Aerobic Exercise.

What condition does NCT05379920 study?

NCT05379920 studies Concussion, Brain.

Is NCT05379920 still recruiting?

NCT05379920 is currently completed. Last updated 3 January 2024.

Are results published for NCT05379920?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2024-01-03 · How we verify

NCT05379920

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Salivary Biomarkers for Concussion Recovery

Completed NA Results posted Last updated 3 January 2024

What this trial tests

NA trial testing High Volume Aerobic Exercise in Concussion, Brain in 60 participants. Completed in 13 January 2023.

Timeline

22 March 2022

Primary endpoint
13 January 2023

13 January 2023

Quick facts

Lead sponsor	State University of New York at Buffalo
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	60
Start date	22 March 2022
Primary completion	13 January 2023
Estimated completion	13 January 2023
Sites	1 location across United States

Drugs / interventions tested

High Volume Aerobic Exercise
Low Volume Aerobic Exercise

Conditions studied

Concussion, Brain — all drugs for Concussion, Brain →

Sponsor

State University of New York at Buffalo

Who can join

Adults 13 to 18, any sex, with Concussion, Brain. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Persistent Post Concussion Symptoms (PPCS) (Yes/No) Primary · 28 days

PPCS is defined as more recovery that occurs 28 days or more from the day of concussive injury (yes) or before 28 days (no). Recovery is defined as asymptomatic, exercise tolerant and confirmation by independent medical examination.

Group	Value	95% CI
Concussed Participants Group 1	4
Concussed Participants Group 2	4

Sponsor's own description

The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise. The investigators hypothesize salivary BDNF and specific miRNA signatures will change in a statistically significant manner as participants proceed from injury to recovery and participants who show recovery in ANS regulation will show significant differences in salivary BDNF and specific miRNA expression. This study also aims to determine if BDNF and/or specific miRNA can serve as biomarkers of the return of ANS function in concussed patients. The basic premise here is that the volume of exercise will significantly affect the rate of change in the expression of salivary BDNF and miRNA from injury to recovery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Sex Differences in Response to Low- Versus High-Volume Aerobic Exercise for Sport-Related Concussion: A Pilot Randomized Controlled Trial.
Chizuk HM, Castro E, Robinson S, Sayeed J, et al · · 2025 · cited 2× · PMID 40237613 · DOI 10.1097/htr.0000000000001061

Verify or expand the search:

Other recruiting trials for Concussion, Brain

Currently open trials in the same condition.

NCT06956417 — REhabilitation of MEMory Symptoms After BRain Concussion · NA · recruiting
NCT06739785 — Turkish Translation of SportsConcussion Assesment Tool 6 · active not recruiting
NCT06270290 — The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls · recruiting
NCT06208813 — Creatine Supplementation in Concussion Recovery · NA · recruiting
NCT06036147 — Concussion Health Improvement Program · NA · recruiting

Other State University of New York at Buffalo trials

Trials by the same sponsor.

NCT07072767 — Hybrid Dissemination Study of A Digital-Analog Intervention to Increase Live Donor Kidney Transplantation · NA · not yet recruiting
NCT07140848 — CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes · NA · not yet recruiting
NCT07433959 — Neuromodulation to Improve Grasping Function After SCI · NA · not yet recruiting
NCT07403539 — Speech Learning and Speech Production in Parkinson's Disease · NA · recruiting
NCT05367362 — Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute · Phase 2 · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05379920 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by State University of New York at Buffalo
Last refreshed: 3 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05379920.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing