Adults 12 to 18, any sex, with Depression in Adolescence. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change From Baseline in Self-management at 3 MonthsPrimary· From baseline to 3 months
Adolescents will be asked the Partners in Health Scale The revised Partners in Health Scale (Smith 2016) assesses self-management with respect to a chronic condition, with regard to active involvement of a patient in managing their condition. Total scores range from 0 to 96 with higher scores indicating worse self-management.
A larger negative change in self-management score means an improvement in self-management.
Group
Value
95% CI
Usual Care
12
± 14.3
MoodRing
-1.84
± 16.04
Quality of Depression Management: Depression Symptom ReassessmentSecondary· 3 months
Attendance at a healthcare provider visit for depression symptom reassessment within 3 months (yes/no) measured by adolescent or parent self-report (yes if any are yes, no if all are no). The metric reported will be percentage of individuals per study arm with a 'yes' result.
Group
Value
95% CI
Usual Care
20
MoodRing
24
Quality of Depression Management: Medication AdherenceSecondary· 3 months
Out of adolescents who are taking an antidepressant, receipt of at least 60 consecutive days (yes/no) measured by adolescent self-report. The metric reported will be percentage of individuals per study arm with a 'yes' result.
Group
Value
95% CI
Usual Care
16
MoodRing
12
Quality of Depression Management: Therapy AdherenceSecondary· 3 months
Out of adolescents who report being referred for psychotherapy, receipt of at least 3 sessions within 3 months (yes/no) measured by adolescent and parent self-report (yes if any are yes, no if all are no). The metric reported will be percentage of individuals per study arm with a 'yes' result.
Group
Value
95% CI
Usual Care
15
MoodRing
14
Healthcare Utilization for Acute Care or Primary Care (for Non Mental-health Reason)Secondary· 3 month
Average Number of visits for (greater number as reported by adolescent self-report and parent self-report):
1. urgent care;
2. emergency room;
3. inpatient hospitalization;
4. acute primary care provider visit for non-mental health related concern;
5. medical subspecialist visit
6. surgical subspecialist visit
Urgent Care Visits
Group
Value
95% CI
Usual Care
0.21
± 0.53
MoodRing
0.20
± 0.48
Emergency Room
Group
Value
95% CI
Usual Care
0.10
± 0.31
MoodRing
0.22
± 0.54
Inpatient Hospitalization
Group
Value
95% CI
Usual Care
0.10
± 0.39
MoodRing
0
± 0
Acute PCP visit non mental health
Group
Value
95% CI
Usual Care
0.52
± 0.79
MoodRing
0.44
± 0.95
Medical Subspecialist Visit
Group
Value
95% CI
Usual Care
0.62
± 0.94
MoodRing
0.37
± 0.71
Surgical Subspecialist Visit
Group
Value
95% CI
Usual Care
0.15
± 0.46
MoodRing
0.15
± 0.53
Depression Severity at 3 MonthsSecondary· 3 months
Adolescents will be asked the PHQ-9 Patient Health Questionnaire-9 measures depression severity with a score ranging from 0 to 27, a higher score indicating greater severity.
Group
Value
95% CI
Usual Care
11.19
± 3.56
MoodRing
11.17
± 5.14
Sleep-Related Impairment at 3 MonthsSecondary· 3 months
Adolescents will respond to the PROMIS Pediatric Sleep-Related Impairment scale. This scale has four questions with response options of never, almost never, sometimes, almost always, and always, ranges from 4 to 19 with higher scores indicating higher levels of sleep-related impairment.
Group
Value
95% CI
Usual Care
13.12
± 3.85
MoodRing
13.17
± 3.81
Sleep Disturbance at 3 MonthsSecondary· 3 months
Adolescents will respond to the PROMIS Pediatric Sleep Disturbance scale. This scale has four questions, the second (sleeping through the night) being reverse-scored, with response options of never, almost never, sometimes, almost always, and always, ranges from 4 to 20 with higher scores indicating higher levels of sleep disturbance.
Group
Value
95% CI
Usual Care
13.48
± 2.74
MoodRing
13.67
± 3.67
Self-Efficacy at 3 MonthsSecondary· 3 months
Adolescents will be asked the Mental Health Self-efficacy Scale (MHSES) The Mental Health Self-efficacy Scale (Clarke, 2014) measures one's belief in one's capability to perform mental health self-care behaviors. The score ranges from 6 to 60, with higher scores indicating higher confidence in mental health selfcare.
Group
Value
95% CI
Usual Care
33.62
± 9.43
MoodRing
35.72
± 9.77
Self-management Behavior at 3 MonthsSecondary· 3 months
Adolescents will be asked based on Question 12 of Partners in Health Scale about self-management behavior. This question asks the average amount of time (options including Daily, More than once a week, Once a week, Once a month, Once a semester, Once a year, Less than once a year, Never) spent in potentially useful self-management activities. Each time category will be described by a percentage. Each of the following are asked individually: (1) created to-do lists to help me focus; (2) found strategies to create pleasurable distractions; (3) engaged in some physical activity (cycling, walking,
Created to-do lists to help me focus
Group
Value
95% CI
Usual Care
4
MoodRing
5
Usual Care
3
MoodRing
3
Usual Care
3
MoodRing
5
Usual Care
7
MoodRing
0
Found strategies to create pleasurable distractions
Group
Value
95% CI
Usual Care
2
MoodRing
5
Usual Care
7
MoodRing
6
Usual Care
9
MoodRing
3
Usual Care
3
MoodRing
7
Engaged in some moderate physical activity (cycling, walking, etc.)
Group
Value
95% CI
Usual Care
2
MoodRing
11
Usual Care
8
MoodRing
1
Usual Care
9
MoodRing
10
Usual Care
4
MoodRing
2
Set realistic short-term goals
Group
Value
95% CI
Usual Care
2
MoodRing
4
Usual Care
5
MoodRing
3
Usual Care
1
MoodRing
7
Usual Care
7
MoodRing
2
Made sure I had a good day/night routine and got enough sleep
Group
Value
95% CI
Usual Care
1
MoodRing
4
Usual Care
10
MoodRing
8
Usual Care
5
MoodRing
6
Usual Care
3
MoodRing
2
Ensured enough rest to avoid getting exhausted
Group
Value
95% CI
Usual Care
2
MoodRing
2
Usual Care
7
MoodRing
8
Usual Care
9
MoodRing
6
Usual Care
1
MoodRing
5
Left the house regulary
Group
Value
95% CI
Usual Care
5
MoodRing
9
Usual Care
12
MoodRing
10
Usual Care
5
MoodRing
2
Usual Care
3
MoodRing
1
Ate healthy
Group
Value
95% CI
Usual Care
4
MoodRing
3
Usual Care
14
MoodRing
12
Usual Care
5
MoodRing
4
Usual Care
1
MoodRing
2
Social Support at 3 MonthsSecondary· 3 months
Adolescents will be asked the Medical Outcomes Study Social Support Survey The Medical Outcome Study Social Support Scale (Sherbourne, 1991) measures types of social support. Each item ranges from 1 to 5 and the total score is averaged and ranges from 1 to 5, with higher levels associated with greater support.
Group
Value
95% CI
Usual Care
3.66
± 0.84
MoodRing
4.08
± 0.72
Change in Self-management at 6 MonthsSecondary· From baseline to 6 months
Adolescents will be asked the Partners in Health Scale The revised Partners in Health Scale (Smith 2016) assesses self-management with respect to a chronic condition, with regard to active involvement of a patient in managing their condition. Total scores range from 0 to 96 with higher scores indicating worse self-management.
A larger negative change in self-management score means an improvement in self-management.
Group
Value
95% CI
Usual Care
-1.55
± 13.3
MoodRing
-4.6
± 16.2
Sponsor's own description
The MoodRing intervention is a mobile application for adolescents, parents, and an accompanying web-based clinician portal which enables adolescents to monitor their mood through the use of passively collected smartphone data. This randomized controlled trial will evaluate whether MoodRing as compared to usual care improves the quality of depression management.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ana Radovic
Last refreshed: 14 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05376358.