NCT05374616 is a clinical trial of Observation in TANGO2-related Disorder, sponsored by Baylor College of Medicine.

Who is sponsoring NCT05374616?

NCT05374616 is sponsored by Baylor College of Medicine.

What drugs are being tested in NCT05374616?

Interventions in NCT05374616: Observation.

What condition does NCT05374616 study?

NCT05374616 studies TANGO2-related Disorder.

Is NCT05374616 still recruiting?

NCT05374616 is currently recruiting now. Last updated 1 October 2025.

Last reviewed 2025-10-01 · How we verify

NCT05374616

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Natural History Study and Establishment of a Biorepository-TANGO2-related Disorder

Recruiting now Last updated 1 October 2025

What this trial tests

trial testing Observation in TANGO2-related Disorder in 300 participants. Currently enrolling.

Timeline

18 May 2018

Primary endpoint
1 January 2030

1 January 2030

Quick facts

Lead sponsor	Baylor College of Medicine
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	300
Start date	18 May 2018
Primary completion	1 January 2030
Estimated completion	1 January 2030
Sites	1 location across United States

Drugs / interventions tested

Observation

Conditions studied

TANGO2-related Disorder — all drugs for TANGO2-related Disorder →

Sponsor

Baylor College of Medicine

Who can join

0 Days and older, any sex, with TANGO2-related Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study aims to establish a biorepository of individuals with TANGO2 deficiency to support scientific research and establish a comprehensive clinical database of affected individuals to understand the disease course.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism.
Lujan AL, Foresti O, Sugden C, Brouwers N, et al · · 2023 · cited 28× · PMID 36961129 · DOI 10.7554/elife.85345
Early initiation of B-vitamin supplementation may reduce symptoms and explain intrafamilial variability: Insights from two sibling pairs from the TANGO2 natural history study.
Miyake CY, Ehsan SA, Zhang L, Mackenzie SJ, et al · · 2023 · cited 11× · PMID 37421366 · DOI 10.1002/ajmg.a.63331
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Xu W, Cao Y, Stephens SB, Arredondo MJ, et al · · 2024 · cited 5× · PMID 38855866 · DOI 10.1172/jci.insight.171005

Verify or expand the search:

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Trials testing the same drug.

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Other Baylor College of Medicine trials

Trials by the same sponsor.

NCT07513194 — GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT) · Phase 1 · not yet recruiting
NCT05855824 — Toddler Biomarker of Nutrition Study · NA · not yet recruiting
NCT06738628 — Disposable Endoscope Platform in Third Space Endoscopic Procedures · not yet recruiting
NCT06834997 — Dronabinol As an Adjunct for Reducing Pain (DARP)-Texas Children's Hospital · Phase 2 · withdrawn
NCT07387614 — WEB-BASED SUPPORT PROGRAM FOR CAREGIVERS OF VETERANS WITH DEMENTIA DISCHARGED FROM SKILLED NURSING FACILITIES TO HOME · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05374616 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Baylor College of Medicine
Last refreshed: 1 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05374616.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing