Last reviewed · How we verify
NCT05373927: MSOT_IC
Calf Muscle Perfusion in Patients With Intermittent Claudication by Non-invasive MSOT
trial testing Multispectral Optoacoustic Tomography (MSOT) in Peripheral Vascular Diseases in 100 participants. Status unknown.
30 September 2022
Quick facts
| Lead sponsor | Ulrich Rother |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 20 June 2022 |
| Primary completion | 30 September 2022 |
| Estimated completion | 30 September 2022 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Multispectral Optoacoustic Tomography (MSOT)
Conditions studied
- Peripheral Vascular Diseases — all drugs for Peripheral Vascular Diseases →
- Peripheral Arterial Disease — all drugs for Peripheral Arterial Disease →
- Intermittent Claudication — all drugs for Intermittent Claudication →
Sponsor
Ulrich Rother
Who can join
18 and older, any sex, with Peripheral Vascular Diseases or Peripheral Arterial Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of the proposed study is to define independent parameters for the diagnostic assessment of the perfusion situation of the calf muscle based on multispectral optoacoustic tomography (MSOT) in a cross-sectional collective of patients with PAD in Fontaine stage II (intermittent claudication) and a healthy control collective (study group 1). The results will be validated using an independent validation group (study group 2).
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication.
Caranovic M, Kempf J, Li Y, Regensburger AP, et al · · 2025 · cited 4× · PMID 40133711 · DOI 10.1038/s43856-025-00801-1 -
Shortcut learning leads to sex bias in deep learning models for photoacoustic tomography.
Knopp M, Bender CJ, Holzwarth N, Li Y, et al · · 2025 · cited 1× · PMID 40343639 · DOI 10.1007/s11548-025-03370-9 -
Derivation and validation of a non-invasive optoacoustic imaging biomarker for patients with intermittent claudication
Caranovic M, Kempf J, Li Y, Regensburger AP, et al · · 2023 · DOI 10.1101/2023.10.19.23297246
Verify or expand the search:
- PubMed search for NCT05373927
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Multispectral Optoacoustic Tomography (MSOT)
Trials testing the same drug.
- NCT06716892 — Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic Tomography · recruiting
- NCT06541496 — Influence of Fitzpatrick Skin Phototype and Body Mass Index on Non-invasive Optoacoustic Imaging · recruiting
- NCT05935852 — Contrast-enhanced Multispectral Optoacoustic Tomography for Non-invasive Assessment of Diabetic Gastroparesis · NA · unknown
- NCT05110677 — Pilot Study of Topographic Imaging of the Calf Muscle in Patients With PAD Using 3D Reconstruction of MSOT Images · unknown
- NCT04650867 — Non Invasive Characterization of Pediatric Inflammatory Bowel Diseases Using Multispectral Optoacoustic Tomography · completed
Other recruiting trials for Peripheral Vascular Diseases
Currently open trials in the same condition.
- NCT06094491 — Virtual Diabetes Group Visits Across Health Systems · Phase 2 · active not recruiting
- NCT06032065 — SMART Exercise for PAD · Phase 3 · recruiting
- NCT06300450 — Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not · NA · recruiting
- NCT04916340 — Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3 · NA · recruiting
- NCT04016649 — The Mechanical Characterisation of Human Saphenous and Popliteal Vein · recruiting
Other Ulrich Rother trials
Trials by the same sponsor.
- NCT05773534 — Calf Muscle Perfusion in Patients With Intermittent Claudication by 3D-reconstruction of MSOT (MSOT_IC_3D) · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05373927 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ulrich Rother
- Last refreshed: 27 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05373927.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing