Last reviewed · How we verify
NCT05372159: VMAP
Vanderbilt Memory and Aging Project
trial testing none, observational study in Alzheimer Disease in 1,000 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Vanderbilt University Medical Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 17 September 2012 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- none, observational study
Conditions studied
- Alzheimer Disease — all drugs for Alzheimer Disease →
- Aging — all drugs for Aging →
- Aged, 80 and Over — all drugs for Aged, 80 and Over →
- Biomarkers — all drugs for Biomarkers →
Sponsor
Vanderbilt University Medical Center
Who can join
60 and older, any sex, with Alzheimer Disease or Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults. Adjusting for relevant clinical covariates, we will test the hypothesis that vascular health is associated with clinical, brain magnetic resonance imaging (MRI), neuropsychological, and cerebrospinal fluid markers of early cerebrovascular and Alzheimer's disease changes (i.e., prior to the onset of significant cognitive decline or dementia). Secondarily, we will examine medical and genetic factors that might mediate associations between vascular health and brain aging, such as inflammatory processes, insulin resistance, and genetic factors (e.g., APOE, a susceptibility risk factor for dementia). Findings will advance knowledge regarding the role that vascular health plays in brain aging.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Sphingolipid metabolism in brain insulin resistance and neurological diseases.
Mei M, Liu M, Mei Y, Zhao J, et al · · 2023 · cited 29× · PMID 37867511 · DOI 10.3389/fendo.2023.1243132 -
SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies.
Kuhn E, Klinger HM, Amariglio RE, Wagner M, et al · · 2025 · cited 7× · PMID 39985404 · DOI 10.1002/alz.14307
Verify or expand the search:
- PubMed search for NCT05372159
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05372159 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
- Last refreshed: 6 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05372159.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing