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NCT05369819
Effect of Midazolam Premedication on Opioid-induced Mask Ventilation Difficulty
Phase 4 trial testing Midazolam in Anesthesia Complication in 120 participants. Completed in 3 January 2024.
2 January 2024
Quick facts
| Lead sponsor | Karaman Training and Research Hospital |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 24 May 2022 |
| Primary completion | 2 January 2024 |
| Estimated completion | 3 January 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Midazolam (midazolam) — full drug profile →
- Saline
Conditions studied
- Anesthesia Complication — all drugs for Anesthesia Complication →
Sponsor
Karaman Training and Research Hospital
Who can join
Adults 18 to 60, any sex, with Anesthesia Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Mask ventilation has great importance during anesthesia induction because it is the only way to oxygenate patients who have lost consciousness and spontaneous breathing. Opioid-derived drugs used in anesthesia induction may cause difficulty in mask ventilation due to their chest wall rigidity and respiratory depressant effects. Adequate muscle relaxation and depth of anesthesia may assist with mask ventilation. It is known that premedication reduces anxiety and has a relaxing effect on airway muscles. Midazolam is frequently used in premedication because it has a rapid onset of action and does not cause hemodynamic changes. In addition, midazolam may relax the airway by acting directly on the airway smooth muscle and thus facilitate mask ventilation during anesthesia induction. In this study, the investigators will evaluate the effect of midazolam premedication on the mask ventilation after induction with remifentanil.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05369819
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Anesthesia Complication
Currently open trials in the same condition.
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- NCT06639737 — Preoperative Blood Volume Optimization Using Transthoracic Echocardiography · NA · recruiting
- NCT06498076 — Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine · NA · recruiting
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- NCT05991453 — Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial · NA · recruiting
Other Karaman Training and Research Hospital trials
Trials by the same sponsor.
- NCT07130552 — Comparison of Distal IPACK and Popliteal Plexus Block Combined With Femoral Triangle Block After Total Knee Arthroplasty · NA · recruiting
- NCT07102407 — Effect of a Constructivist Educational Program on Preventing Ventilator-Associated Pneumonia in Intensive Care Units · NA · recruiting
- NCT06616740 — Effects of Paratracheal Compression and Cricoid Compression on LMA ProSeal Placement · NA · completed
- NCT06605937 — The Effect of Postoperative Eustachian Milking Maneuver on Eustachian Tube Dysfunction · completed
- NCT06634680 — Effects of Different Parental Involvement on Anxiety and Delirium · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05369819 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karaman Training and Research Hospital
- Last refreshed: 5 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05369819.
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