Last reviewed · How we verify
NCT05369182
Multicenter Registry of Coronary Flow-Derived Indexes for Coronary Microvascular Disease (Multicenter FLOW-CMD Registry)
trial testing Invasive physiologic assessment in Coronary Microvascular Disease in 1,003 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2025
Quick facts
| Lead sponsor | Samsung Medical Center |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 1,003 |
| Start date | 22 April 2022 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2027 |
| Sites | 7 locations across South Korea |
Drugs / interventions tested
- Invasive physiologic assessment
- Intravascular imaging
Conditions studied
- Coronary Microvascular Disease — all drugs for Coronary Microvascular Disease →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Ischemic Heart Disease — all drugs for Ischemic Heart Disease →
Sponsor
Samsung Medical Center
Who can join
18 and older, any sex, with Coronary Microvascular Disease or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Multicenter FLOW-CMD registry is a prospective, multi-center, registry study. The aim of the study is to evaluate prognostic implications of coronary microvascular disease (CMD) in patients with ischemic heart disease (IHD) undergoing revascularization decision using FFR or other non-hyperemic pressure ratios.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea.
Lee JM, Lee SH, Gim DH, Lee SY, et al · · 2026 · PMID 42167298 · DOI 10.1016/s0140-6736(26)00666-5
Verify or expand the search:
- PubMed search for NCT05369182
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Samsung Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05369182 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Samsung Medical Center
- Last refreshed: 12 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05369182.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing