NCT05365620

In-line Mechanical Insufflation-Exsufflation in the Management of Ventilated Patients

Completed NA Last updated 12 May 2022

What this trial tests

NA trial testing Mechanical In-Line Inexsufflation in Ventilation Therapy; Complications in 120 participants. Completed in 1 July 2018.

Timeline

1 July 2015

Primary endpoint
1 July 2018

1 July 2018

Quick facts

Lead sponsor	Alyn Pediatric & Adolescent Rehabilitation Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	120
Start date	1 July 2015
Primary completion	1 July 2018
Estimated completion	1 July 2018

Drugs / interventions tested

• Mechanical In-Line Inexsufflation
• catheter suction

Conditions studied

• Ventilation Therapy; Complications — all drugs for Ventilation Therapy; Complications →
• Airway Clearance Impairment — all drugs for Airway Clearance Impairment →

Sponsor

Alyn Pediatric & Adolescent Rehabilitation Hospital

Who can join

Adults 18 to 75, any sex, with Ventilation Therapy; Complications or Airway Clearance Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Catheter suction (CS), the standard method for airway secretion management during mechanical ventilation, is invasive and has significant hemodynamic and traumatic side effects. In-line mechanical insufflation-exsufflation (IL-MIE) is a new, noninvasive technology that clears secretions by cough-simulation, without interrupting ongoing ventilation. It is not known whether IL-MIE can be safely and effectively used as an alternative to CS in ventilated patients. Methods: A randomized, controlled, non-inferiority study comparing a standard protocol of CS, with automatic IL-MIE (CoughSync, Ruxin Medical Systems, Beijing) performed every 30 minutes, with CS added only if needed, in post-operative ventilated patients.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.