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NCT05363527: ARIA
Aging and Reward System Response to Inflammation and Anxiety Study
Phase 1 trial testing Endotoxin in Anhedonia in 40 participants. Completed in 8 December 2025.
8 December 2025
Quick facts
| Lead sponsor | University of California, Los Angeles |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 40 |
| Start date | 29 March 2023 |
| Primary completion | 8 December 2025 |
| Estimated completion | 8 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Endotoxin — full drug profile →
- Placebo
Conditions studied
- Anhedonia — all drugs for Anhedonia →
- Inflammation — all drugs for Inflammation →
- Anxiety — all drugs for Anxiety →
- Aging — all drugs for Aging →
Sponsor
University of California, Los Angeles
Who can join
Adults 60 to 80, any sex, with Anhedonia or Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05363527
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Endotoxin
Trials testing the same drug.
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- NCT04310423 — An Inflammatory Challenge Using Endotoxin · Phase 2 · completed
- NCT03848715 — Sleep and Healthy Aging Research on Depression for Younger Women · Phase 1 · completed
- NCT03256760 — Sleep and Healthy Aging Research for Depression (SHARE-D) Study · Phase 1 · completed
- NCT03083171 — Adrecizumab-LPS Study · Phase 1 · completed
Other recruiting trials for Anhedonia
Currently open trials in the same condition.
- NCT07493369 — Positive Affect Treatment for Spanish-Speaking Individuals · NA · active not recruiting
- NCT07319143 — The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health · NA · recruiting
- NCT07490353 — Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects · Phase 1 · recruiting
- NCT06665620 — Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents · NA · active not recruiting
- NCT06829953 — Get ActivE Study for At-risk Youth · NA · recruiting
Other University of California, Los Angeles trials
Trials by the same sponsor.
- NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
- NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
- NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
- NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
- NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05363527 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
- Last refreshed: 11 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05363527.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing