Who is sponsoring NCT05362422?

NCT05362422 is sponsored by Helsinki University Central Hospital.

What drugs are being tested in NCT05362422?

Interventions in NCT05362422: long-term paired associative stimulation, sham long-term paired associative stimulation.

What condition does NCT05362422 study?

NCT05362422 studies Spinal Cord Injury Cervical, Neuropathic Pain.

Is NCT05362422 still recruiting?

NCT05362422 is currently completed. Last updated 25 September 2023.

Last reviewed 2023-09-25 · How we verify

NCT05362422

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PAS for Post-SCI Neuropathic Pain

Completed NA Last updated 25 September 2023

What this trial tests

NA trial testing long-term paired associative stimulation in Spinal Cord Injury Cervical in 5 participants. Completed in 22 September 2023.

Timeline

22 April 2022

Primary endpoint
22 May 2023

22 September 2023

Quick facts

Lead sponsor	Helsinki University Central Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	5
Start date	22 April 2022
Primary completion	22 May 2023
Estimated completion	22 September 2023
Sites	1 location across Finland

Drugs / interventions tested

long-term paired associative stimulation
sham long-term paired associative stimulation

Conditions studied

Spinal Cord Injury Cervical — all drugs for Spinal Cord Injury Cervical →
Neuropathic Pain — all drugs for Neuropathic Pain →

Sponsor

Helsinki University Central Hospital

Who can join

Adults 18 to 75, any sex, with Spinal Cord Injury Cervical or Neuropathic Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles. In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and SCI- associated neuropathic pain, and investigate its effectiveness for neuropathic pain treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury - a pilot trial.
Holopainen K, Pohjonen M, Kirveskari E, Vaalto S, et al · · 2026 · PMID 41776169 · DOI 10.1038/s41394-026-00729-1
The Effect of Paired Associative Stimulation with High-intensity Cortical Component and High-frequency Peripheral Component on Neuropathic Pain in Incomplete Spinal Cord Injury Patients
Holopainen K, Pohjonen M, Kirveskari E, Vaalto S, et al · · 2025 · DOI 10.21203/rs.3.rs-6887477/v1

Verify or expand the search:

Other trials of long-term paired associative stimulation

Trials testing the same drug.

NCT03104803 — Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin · NA · completed
NCT03045744 — Long-term PAS in Rehabilitation After SCI · NA · completed

Other recruiting trials for Spinal Cord Injury Cervical

Currently open trials in the same condition.

NCT06867809 — Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury · NA · recruiting
NCT07225582 — Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia · NA · recruiting
NCT07135583 — Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury · NA · recruiting
NCT06841770 — A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury · Phase 1 · recruiting
NCT06903416 — Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial · Phase 2, PHASE3 · recruiting

Other Helsinki University Central Hospital trials

Trials by the same sponsor.

NCT07423637 — The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectivene · NA · not yet recruiting
NCT07462559 — KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study · Phase 1 · not yet recruiting
NCT07458984 — FMT Capsules for rCDI · Phase 3 · not yet recruiting
NCT07001423 — ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly · NA · recruiting
NCT07155629 — Neoadjuvant Treatment vs Upfront Surgery for Left-Sided Pancreatic Cancer · Phase 3 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05362422 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Helsinki University Central Hospital
Last refreshed: 25 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05362422.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing