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NCT05360186
New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT
NA trial testing MateRegen® gel (BioRegen) in First Trimester Abortion in 150 participants. Currently enrolling.
14 May 2026
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 150 |
| Start date | 14 June 2022 |
| Primary completion | 14 May 2026 |
| Estimated completion | 15 May 2026 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- MateRegen® gel (BioRegen)
Conditions studied
- First Trimester Abortion — all drugs for First Trimester Abortion →
- Surgical Abortion — all drugs for Surgical Abortion →
- Miscarriage With Afibrinogenemia — all drugs for Miscarriage With Afibrinogenemia →
Sponsor
Chinese University of Hong Kong
Who can join
Adults 18 to 50, female only, with First Trimester Abortion or Surgical Abortion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester miscarriage. * To study the severity and extent of the IUA as assessed by the AFS and ESGE adhesion score in both groups of patients. * To examine the rate of complications or side effects with the NCH gel. * To assess the subsequent menstrual history and reproductive outcome in both groups of patients.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Hydrogels in the clinic: An update.
Clegg JR, Adebowale K, Zhao Z, Mitragotri S. · · 2024 · cited 64× · PMID 39545079 · DOI 10.1002/btm2.10680 -
Modelling and targeting mechanical forces in organ fibrosis.
Mascharak S, Guo JL, Griffin M, Berry CE, et al · · 2024 · cited 23× · PMID 39552705 · DOI 10.1038/s44222-023-00144-3
Verify or expand the search:
- PubMed search for NCT05360186
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05360186 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 13 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05360186.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing