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NCT05352854

In Vivo Morphological Changes of Ciliary Body and Trabecular Meshwork in High Myopia Eyes With Open-angle Glaucoma in Their Accommodation Induced by Pilocarpine

Status unknown NA Last updated 24 April 2022
What this trial tests

NA trial testing 0.5% pilocarpine eye drops in Glaucoma in 120 participants. Status unknown.

Timeline
1 May 2022
Primary endpoint
1 June 2022
1 August 2022

Quick facts

Lead sponsorYune Zhao
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationnon randomized
Designparallel
Maskingnone
Primary purposeother
Enrollment120
Start date1 May 2022
Primary completion1 June 2022
Estimated completion1 August 2022

Drugs / interventions tested

Conditions studied

Sponsor

Yune Zhao — full company profile →

Who can join

Adults 18 to 60, any sex, with Glaucoma or Myopia. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Sponsor's own description

Glaucoma is the leading cause of irreversible blindness worldwide. Although the pathogenesis remains unclear, pathologic increase in intraocular pressure (IOP) due to blocked aqueous outflow through the trabecular-Schlemm canal is known to be an important risk factor, and reduction of IOP is the only clinically validated way to retard the progression of OAG. Ciliary muscle plays a central role in the trabecular meshwork-Schlemm canal outflow pathway. Clinical evidence suggests that ciliary muscle contraction stimulated by cholinergic receptor agonist and retraction of ciliary body position after cataract surgery can dilate the lumen of Schlemm canal and reduce IOP. Currently, Ultrasound biomicroscopy (UBM) can obtain two-dimensional images of the anterior segment using high-frequency Ultrasound transducers in medical imaging studies of the ciliary body - trabecular meshwork -Schlemm canal complex. UBM has better tissue penetration than Optical coherence tomography (OCT) and can image the ciliary body better, but it has a lower resolution (30um to 50um) and is poor at imaging tiny tissues such as trabecular meshwork and Schlemm canal. The latest swept-source OCT (SS-OCT) has faster image capture rate (1000000 A scans/SEC), stronger penetration and higher resolution (8um axial resolution and 20um transverse resolution). The structure and morphology of ciliary body-trabecular meshwork-Schlemm canal complex can be clearly photographed. The investigators intend to use CASIA2 to image the ciliary body-trabecular meshwork-Schlemm canal complex before and after administration of pilocarpine in healthy individuals and patients with glaucoma to assess the effect of pilocarpine on the anatomy of the ciliary body-trabecular meshwork-Schlemm canal complex.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. The Change of Ciliary Muscle-Trabecular Meshwork-Schlemm Canal Complex after Phacoemulsification using Swept-Source-Optical Coherence Tomography.
    Li Z, Wu X, Ji X, Zhu Z, et al · · 2025 · PMID 39837299 · DOI 10.1159/000543303

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Other recruiting trials for Glaucoma

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