Last reviewed · How we verify
NCT05352074
STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation
NA trial testing Total colectomy with ileorectal anastomosis in Slow Transit Constipation in 252 participants. Participants enrolled and being followed up; not accepting new ones.
1 May 2025
Quick facts
| Lead sponsor | Third Military Medical University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 252 |
| Start date | 27 March 2022 |
| Primary completion | 1 May 2025 |
| Estimated completion | 1 May 2028 |
| Sites | 14 locations across China |
Drugs / interventions tested
- Total colectomy with ileorectal anastomosis
- Subtotal colectomy with cecal-rectal anastomosis
Conditions studied
- Slow Transit Constipation — all drugs for Slow Transit Constipation →
- Surgery — all drugs for Surgery →
Sponsor
Third Military Medical University
Who can join
Adults 18 to 80, any sex, with Slow Transit Constipation or Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Total colectomy with ileorectal anastomosis is a traditional surgical option for slow transit constipation (STC). Subtotal colectomy with caecorectal anastomosis have been reported to be a potential alternative approach. Thus, the optimal surgical option for STC is controversial.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Total colectomy with ileorectal anastomosis versus subtotal colectomy with cecal-rectal anastomosis for slow transit constipation: protocol for a multicenter randomized controlled trial (STOPS trial).
Tian Y, Guo M, Bu F, Ni L, et al · · 2025 · PMID 41074220 · DOI 10.1186/s13063-025-09049-5 -
STOPS study: total colectomy with ileorectal anastomosis versus subtotal colectomy with cecal-rectal anastomosis for slow transit constipation: a study protocol for a multicenter randomized controlled trial
Tian Y, Guo M, Fu T, Gao F, et al · · 2024 · DOI 10.21203/rs.3.rs-3967026/v1
Verify or expand the search:
- PubMed search for NCT05352074
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Slow Transit Constipation
Currently open trials in the same condition.
- NCT07277907 — Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation · Phase 3 · recruiting
- NCT06911749 — MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders · NA · recruiting
Other Third Military Medical University trials
Trials by the same sponsor.
- NCT07536477 — High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema · NA · not yet recruiting
- NCT07488507 — Diagnostic Value and Safety of Combined Biopsy for Mediastinal Metastasis of Lung Cancer · NA · recruiting
- NCT07277907 — Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation · Phase 3 · recruiting
- NCT04557995 — Erythrocytapheresis for Chronic Mountain Sickness · NA · recruiting
- NCT07036588 — PARLAR-02 Trial：Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05352074 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Third Military Medical University
- Last refreshed: 14 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05352074.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing