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NCT05351021
Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
Phase 2 trial testing Metformin in Peripheral Neuropathy in 76 participants. Completed in 30 October 2022.
30 October 2022
Quick facts
| Lead sponsor | Mansoura University |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 76 |
| Start date | 12 April 2022 |
| Primary completion | 30 October 2022 |
| Estimated completion | 30 October 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Metformin (metformin) — full drug profile →
- Placebo
Conditions studied
- Peripheral Neuropathy — all drugs for Peripheral Neuropathy →
- Breast Cancer — all drugs for Breast Cancer →
Sponsor
Mansoura University
Who can join
Adults 18 to 80, female only, with Peripheral Neuropathy or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
At present, there are no FDA-approved treatments for chemotherapy-induced neuropathy. Discrete neuro anti-inflammatory effects of metformin support its repurposing as a neuroprotective agent in patients with neurodegenerative diseases. Therefore, this study aims to evaluate the effect of metformin on the amelioration of paclitaxel induced neuropathy in cancer patients.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Metformin: A Dual-Role Player in Cancer Treatment and Prevention.
Galal MA, Al-Rimawi M, Hajeer A, Dahman H, et al · · 2024 · cited 44× · PMID 38612893 · DOI 10.3390/ijms25074083 -
Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies.
Corleto KA, Strandmo JL, Giles ED. · · 2024 · cited 23× · PMID 38543182 · DOI 10.3390/ph17030396 -
Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial.
Bakry HM, Mansour NO, ElKhodary TR, Soliman MM. · · 2023 · cited 17× · PMID 37583905 · DOI 10.3389/fphar.2023.1181312
Verify or expand the search:
- PubMed search for NCT05351021
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Metformin
Trials testing the same drug.
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- NCT07520110 — Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis · Phase 3 · not yet recruiting
- NCT07007221 — Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV · Phase 2 · not yet recruiting
- NCT07585396 — Inositol in Letrozol Resistant PCOS Women · Phase 2, PHASE3 · not yet recruiting
- NCT07226453 — Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma · Phase 2 · not yet recruiting
Other recruiting trials for Peripheral Neuropathy
Currently open trials in the same condition.
- NCT07336381 — Replexa+ Shortwave Diathermy Device for Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy · NA · recruiting
- NCT07025005 — Fenofibrate Role in the Prophylaxis From Peripheral Neuropathy Induced by Bortezomib, Lenalidomide and Dexamethasone (VR · Phase 4 · recruiting
- NCT07163000 — Earlier Diagnosis of Peripheral Neuropathy Using A Simple sCreening Tool (ACT) · active not recruiting
- NCT07055711 — Association Between Work-Related Stress and Peripheral Neuropathic Pain in Female Breast Cancer Post CT · active not recruiting
- NCT06615622 — Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic · recruiting
Other Mansoura University trials
Trials by the same sponsor.
- NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia · NA · not yet recruiting
- NCT07509567 — Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment · NA · not yet recruiting
- NCT07393178 — Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · NA · not yet recruiting
- NCT07436182 — Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. · Phase 4 · not yet recruiting
- NCT07534943 — Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Period · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05351021 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mansoura University
- Last refreshed: 9 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05351021.
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