Who is sponsoring NCT05346588?

NCT05346588 is sponsored by Washington University School of Medicine.

What drugs are being tested in NCT05346588?

Interventions in NCT05346588: Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent.

What condition does NCT05346588 study?

NCT05346588 studies Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Nausea, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm.

Is NCT05346588 still recruiting?

NCT05346588 is currently completed. Last updated 24 November 2023.

Last reviewed 2023-11-24 · How we verify

NCT05346588: THRIVE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

THRIVE Feasibility Trial

Completed Phase 3 Last updated 24 November 2023

What this trial tests

Phase 3 trial testing Anesthetic technique Propofol TIVA in Surgery--Complications in 300 participants. Completed in 28 June 2023.

Timeline

29 September 2022

Primary endpoint
16 April 2023

28 June 2023

Quick facts

Lead sponsor	Washington University School of Medicine
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	other
Enrollment	300
Start date	29 September 2022
Primary completion	16 April 2023
Estimated completion	28 June 2023
Sites	4 locations across United States

Drugs / interventions tested

Anesthetic technique Propofol TIVA
Anesthetic technique inhaled agent

Conditions studied

Surgery--Complications — all drugs for Surgery--Complications →
Anesthesia Complication — all drugs for Anesthesia Complication →
Anesthesia Awareness — all drugs for Anesthesia Awareness →
Anesthesia Emergence Delirium — all drugs for Anesthesia Emergence Delirium →

Sponsor

Washington University School of Medicine

Who can join

18 and older, any sex, with Surgery--Complications or Anesthesia Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

A survey of surgical patients' perspectives and preferences towards general anesthesia techniques and shared-decision making.
Pennington BRT, Politi MC, Abdallah AB, Janda AM, et al · · 2023 · cited 14× · PMID 37592215 · DOI 10.1186/s12871-023-02219-5
Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) pragmatic randomised controlled trial.
Tellor Pennington BR, Colquhoun DA, Neuman MD, Politi MC, et al · · 2023 · cited 8× · PMID 37068889 · DOI 10.1136/bmjopen-2022-070096
Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anaesthesia (THRIVE) randomised controlled trial in the USA: A protocol.
Tellor Pennington BR, Janda AM, Colquhoun DA, Neuman MD, et al · · 2025 · cited 1× · PMID 40953862 · DOI 10.1136/bmjopen-2025-103836
Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Pragmatic Randomized Clinical Trial.
Janda AM, Pennington BRT, Colquhoun DA, Kumar SS, et al · · 2026 · PMID 41950401 · DOI 10.1097/aln.0000000000006089

Verify or expand the search:

Other trials of Anesthetic technique Propofol TIVA

Trials testing the same drug.

NCT05991453 — Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial · NA · recruiting

Other recruiting trials for Surgery--Complications

Currently open trials in the same condition.

NCT05219058 — Reconstruction in Extended MArgin Cancer Surgery · recruiting
NCT04967391 — Tumescence in HNC Skin Graft Reconstruction · Phase 3 · active not recruiting
NCT03561376 — Zinc Oxide Versus Petrolatum Following Skin Surgery · EARLY_PHASE1 · recruiting
NCT05155878 — Prognostic Factors in Periampullary Tumors and Cysts · recruiting
NCT04824066 — The Role of Wearable Devices in Cardiothoracic Surgery: Predicting and Detecting Early Postoperative Complications · recruiting

Other Washington University School of Medicine trials

Trials by the same sponsor.

NCT05521997 — Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer · Phase 2 · not yet recruiting
NCT07101666 — Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer · Phase 2 · not yet recruiting
NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
NCT07419464 — 5-Fluorouracil Response and Optimization STudy (The FROST Trial) · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05346588 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
Last refreshed: 24 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05346588.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing