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NCT05343507
Ketamine to Treat Patients With Post-comatose Disorders of Consciousness
Phase 2, PHASE3 trial testing Ketalar 50 MG/ML Injectable Solution in Disorder of Consciousness in 30 participants. Currently enrolling.
1 May 2025
Quick facts
| Lead sponsor | University of Liege |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 May 2022 |
| Primary completion | 1 May 2025 |
| Estimated completion | 1 May 2026 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Ketalar 50 MG/ML Injectable Solution — full drug profile →
- Placebo
Conditions studied
- Disorder of Consciousness — all drugs for Disorder of Consciousness →
Sponsor
University of Liege
Who can join
Adults 18 to 65, any sex, with Disorder of Consciousness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will run a Randomized Clinical Trial with 30 patients with disorders of consciousness (DoC), with intravenous subanesthetic doses of ketamine. Patients will simultaneously undergo TMS-EEG. The piloting will be done on 3 patients, with EEG only.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions.
Barra ME, Solt K, Yu X, Edlow BL. · · 2024 · cited 11× · PMID 39019729 · DOI 10.1016/j.neurot.2024.e00374
Verify or expand the search:
- PubMed search for NCT05343507
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ketalar 50 MG/ML Injectable Solution
Trials testing the same drug.
- NCT05786365 — Comparison of Emergence/Dysphoric Reaction Frequency of Using 2 Different Doses Ketamine · completed
Other recruiting trials for Disorder of Consciousness
Currently open trials in the same condition.
- NCT06896279 — Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousnes · NA · recruiting
- NCT06515132 — Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation · NA · recruiting
- NCT06469983 — Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial · NA · recruiting
- NCT06527573 — Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness · NA · recruiting
- NCT06635291 — Improving the Diagnostic Accuracy of Children with DoC (IDeAl DesiRE) · recruiting
Other University of Liege trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05343507 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Liege
- Last refreshed: 7 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05343507.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing