NCT05330611 (Trauma-PC2) is a NA clinical trial of Cryoneurolysis of Intercostal Nerves in Rib Fractures, sponsored by Stanford University.

Who is sponsoring NCT05330611?

NCT05330611 is sponsored by Stanford University.

What drugs are being tested in NCT05330611?

Interventions in NCT05330611: Cryoneurolysis of Intercostal Nerves, Standard of Care.

What condition does NCT05330611 study?

NCT05330611 studies Rib Fractures.

Is NCT05330611 still recruiting?

NCT05330611 is currently completed. Last updated 4 February 2026.

Last reviewed 2026-02-04 · How we verify

NCT05330611: Trauma-PC2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis

Completed NA Last updated 4 February 2026

What this trial tests

NA trial testing Cryoneurolysis of Intercostal Nerves in Rib Fractures in 43 participants. Completed in 2 February 2026.

Timeline

21 February 2023

Primary endpoint
2 February 2025

2 February 2026

Quick facts

Lead sponsor	Stanford University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	43
Start date	21 February 2023
Primary completion	2 February 2025
Estimated completion	2 February 2026
Sites	1 location across United States

Drugs / interventions tested

Cryoneurolysis of Intercostal Nerves
Standard of Care

Conditions studied

Rib Fractures — all drugs for Rib Fractures →

Sponsor

Stanford University

Who can join

Adults 18 to 64, any sex, with Rib Fractures. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this research study is to examine the effectiveness of using the Iovera Smart Time 190, for ultrasound-guided cryoneurolysis, in trauma patients 18-64 years old with rib fractures that are not candidates for surgical stabilization. This will offer patients the benefits of cryoneurolysis of the intercostal nerves, thereby providing short and long term pain control while their ribs heal. The Iovera Smart Tip 190 is FDA approved for cryoneurolysis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Chilling the nerve, easing the pain?: A randomized clinical trial evaluating surgeon-administered bedside percutaneous cryoneurolysis for rib fracture pain.
Forrester JD, Tung JT, Knight AW, Wang S, et al · · 2026 · cited 1× · PMID 41604277 · DOI 10.1097/ta.0000000000004885
Early Percutaneous Cryoneurolysis for Pain Control After Rib Fracture for Older Patients: A Prospective Randomized Clinical Trial.
Forrester JD, Abreo A, Earley M, King JM, et al · · 2026 · PMID 41700907 · DOI 10.1097/xcs.0000000000001856

Verify or expand the search:

Other recruiting trials for Rib Fractures

Currently open trials in the same condition.

NCT05642026 — INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures · Phase 4 · recruiting
NCT06853002 — Deep Breathing Exercises and Incentive Spirometry After Rib Fracture · NA · recruiting
NCT06347874 — Cryo Rib Fracture Study · Phase 4 · recruiting
NCT06222333 — Breathing Exercise for Rib Fracture · NA · recruiting
NCT06519929 — Analgesic Techniques for Rib Fractures · Phase 4 · active not recruiting

Other Stanford University trials

Trials by the same sponsor.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT04225949 — Patients Understanding of PROM Graphs · NA · withdrawn
NCT06273098 — School-Based Bladder Health Intervention · NA · withdrawn
NCT04652635 — Management of Nailbed Injuries · NA · withdrawn
NCT05443503 — Stanford Spine Keeper - Managing Your Low Back Pain · NA · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05330611 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 4 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05330611.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing