Who is sponsoring NCT05329727?

NCT05329727 is sponsored by Wonju Severance Christian Hospital.

What drugs are being tested in NCT05329727?

Interventions in NCT05329727: Angiotensin receptor neprilysin inhibitor (ARNI), Renin-Angiotensin System Inhibitor (RAS inhibitor).

What condition does NCT05329727 study?

NCT05329727 studies Heart Failure, Mortality.

Is NCT05329727 still recruiting?

NCT05329727 is currently status unknown. Last updated 1 August 2023.

Last reviewed 2023-08-01 · How we verify

NCT05329727: PARADE-HF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Comparative Effectiveness Between ARNI and ACE Inhibitor/ARB Medication in Patient With HFrEF

Status unknown Last updated 1 August 2023

What this trial tests

trial testing Angiotensin receptor neprilysin inhibitor (ARNI) in Heart Failure in 1,000,000 participants. Status unknown.

Timeline

18 February 2022

Primary endpoint
30 June 2022

31 December 2025

Quick facts

Lead sponsor	Wonju Severance Christian Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	1,000,000
Start date	18 February 2022
Primary completion	30 June 2022
Estimated completion	31 December 2025
Sites	1 location across South Korea

Drugs / interventions tested

Angiotensin receptor neprilysin inhibitor (ARNI) — full drug profile →
Renin-Angiotensin System Inhibitor (RAS inhibitor) — full drug profile →

Conditions studied

Heart Failure — all drugs for Heart Failure →
Mortality — all drugs for Mortality →

Sponsor

Wonju Severance Christian Hospital

Who can join

18 and older, any sex, with Heart Failure or Mortality. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aimed to evaluate the effectiveness, safety, and cost-effectiveness of ARNI and ACEi/ARBs in real-world practice. This study could find out what the unmet medical needs are in real world practice. Furthermore, this study will be helpful to establish the healthcare policy reimbursement policy or clinical practice guideline for HF regarding HF medications to reduce the burden of HF in Korea.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Angiotensin receptor-neprilysin inhibitor adherence and outcomes in heart failure with reduced ejection fraction.
Cho DH, Choi J, Youn JC, Kim MN, et al · · 2025 · cited 8× · PMID 39420468 · DOI 10.1002/ehf2.15117

Verify or expand the search:

Other recruiting trials for Heart Failure

Currently open trials in the same condition.

NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting

Other Wonju Severance Christian Hospital trials

Trials by the same sponsor.

NCT07012499 — QOL and Mental Health Using APD With Remote Monitoring System · NA · enrolling by invitation
NCT07146178 — Long-term Follow-up of Bio-signals and Quality of Recovery Following Implementation of ERAS · NA · not yet recruiting
NCT06675396 — Pharmacogenomics of Mood Disorder in Chronic Kidney Disease Patients · not yet recruiting
NCT06540430 — Digital Based Home Care Service for Ostomy Patients · NA · not yet recruiting
NCT07017088 — Efficacy of Leuconostoc Mesenteroides · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05329727 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Wonju Severance Christian Hospital
Last refreshed: 1 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05329727.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing