NCT05328414 is a Phase 1, PHASE2 clinical trial of Prednisolone in Smell Loss, sponsored by Deraya University.

Who is sponsoring NCT05328414?

NCT05328414 is sponsored by Deraya University.

What drugs are being tested in NCT05328414?

Interventions in NCT05328414: Prednisolone.

What condition does NCT05328414 study?

NCT05328414 studies Smell Loss.

Is NCT05328414 still recruiting?

NCT05328414 is currently completed. Last updated 1 June 2023.

Last reviewed 2023-06-01 · How we verify

NCT05328414

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Preparation and Characterization Intranasal Film Loaded With Steroid as a Local Treatment of Anosmia in Compare to Insulin Intranasal Film

Completed Phase 1, PHASE2 Last updated 1 June 2023

What this trial tests

Phase 1, PHASE2 trial testing Prednisolone in Smell Loss in 200 participants. Completed in 20 May 2023.

Timeline

1 March 2022

Primary endpoint
18 March 2023

20 May 2023

Quick facts

Lead sponsor	Deraya University
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	200
Start date	1 March 2022
Primary completion	18 March 2023
Estimated completion	20 May 2023
Sites	1 location across Egypt

Drugs / interventions tested

Prednisolone — full drug profile →

Conditions studied

Smell Loss — all drugs for Smell Loss →

Sponsor

Deraya University

Who can join

Adults 18 to 50, any sex, with Smell Loss. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a growing step of phase I study published on March 2021. The study was implicated on Minia university on small scale of patient (20) to investigate the impact of insulin as fast dissolving films for intranasal delivery to treat anosmia in post COVID-19 infections. this record will modify the first formulation by addition certain concentration of steroid.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison Between Intranasal Insulin Films Alone and Combined Intranasal Insulin Plus Steroid Films for Post Viral Olfactory Dysfunction.
Hamead K, Ahmed MI, Karim ARAA, Moneim RAA, et al · · 2025 · PMID 40093474 · DOI 10.1007/s12070-024-05296-1

Verify or expand the search:

Other trials of Prednisolone

Trials testing the same drug.

NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
NCT07210008 — "Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity · Phase 3 · not yet recruiting
NCT06953791 — Comparison of Quality of Life During a Flare of Crohn's Disease Treated With Prednisolone or aCDED With PEN in Adult Pat · Phase 2 · recruiting
NCT07052929 — Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators · Phase 1, PHASE2 · recruiting
NCT07252271 — Very Low Dose Prednisolone on Newly Diagnosed Rheumatoid Arthritis · Phase 4 · not yet recruiting

Other recruiting trials for Smell Loss

Currently open trials in the same condition.

NCT06892704 — Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSw · recruiting
NCT06733636 — Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults · NA · recruiting
NCT07021040 — Olfactory Biopsies · NA · recruiting
NCT05364125 — Olfactory Training on Smell Dysfunction Patients in HK · NA · recruiting

Other Deraya University trials

Trials by the same sponsor.

NCT07528625 — Behavioral Interventions as Primary Prevention for Non-Communicable Diseases Among Young People · NA · not yet recruiting
NCT07535827 — Insulin Intratympanic Application · EARLY_PHASE1 · enrolling by invitation
NCT07534280 — Herbal Tea Extract for Management of Rhinosinusitis · NA · completed
NCT07524686 — Spinal Mobilization With Leg Movement Versus Neurodynamic Mobilization in Lumbar Radiculopathy · NA · completed
NCT07368517 — Dry Needling for Mechanical Neck Pain · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05328414 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Deraya University
Last refreshed: 1 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05328414.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing