NCT05327348 is a Phase 3 clinical trial of Intravenous Ascorbate in Oxidative Stress, sponsored by University of Malaya.

Who is sponsoring NCT05327348?

NCT05327348 is sponsored by University of Malaya.

What drugs are being tested in NCT05327348?

Interventions in NCT05327348: Intravenous Ascorbate, Normal Saline 10 mL Injection.

What condition does NCT05327348 study?

NCT05327348 studies Oxidative Stress, Ischemia-reperfusion Injury.

Is NCT05327348 still recruiting?

NCT05327348 is currently status unknown. Last updated 25 November 2022.

Last reviewed 2022-11-25 · How we verify

NCT05327348

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery

Status unknown Phase 3 Last updated 25 November 2022

What this trial tests

Phase 3 trial testing Intravenous Ascorbate in Oxidative Stress in 34 participants. Status unknown.

Timeline

25 September 2022

Primary endpoint
31 July 2023

31 July 2023

Quick facts

Lead sponsor	University of Malaya
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	34
Start date	25 September 2022
Primary completion	31 July 2023
Estimated completion	31 July 2023
Sites	3 locations across Malaysia

Drugs / interventions tested

Intravenous Ascorbate — full drug profile →
Normal Saline 10 mL Injection

Conditions studied

Oxidative Stress — all drugs for Oxidative Stress →
Ischemia-reperfusion Injury — all drugs for Ischemia-reperfusion Injury →

Sponsor

University of Malaya

Who can join

18 and older, any sex, with Oxidative Stress or Ischemia-reperfusion Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Ischemia and reperfusion injury during free flap reconstructive surgery creates a state of increased oxidative stress that can adversely affect the flap outcomes. Ascorbic acid (AA) had been proven to have beneficial effect on end-organ protection and flap survival from ischemia-reperfusion injury via its antioxidant properties. The investigators hypothesise that perioperative parenteral ascorbic acid treatment may reduce oxidative stress among participants undergoing free flap reconstructive surgery along with reduction in inflammatory markers, improved rate of flap viability and wound healing at both donor and recipient sites.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Optimizing perioperative care in autologous breast reconstruction: a narrative review.
Reina Di Nunzio TG, Farhadi J, Grufman V, Speck NE. · · 2026 · PMID 41808815 · DOI 10.21037/gs-2025-1-539

Verify or expand the search:

Other recruiting trials for Oxidative Stress

Currently open trials in the same condition.

NCT07375238 — Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress · NA · recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07244809 — Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adve · NA · recruiting
NCT07152912 — Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy · NA · recruiting
NCT07369232 — Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT) · NA · recruiting

Other University of Malaya trials

Trials by the same sponsor.

NCT07398066 — DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) · NA · not yet recruiting
NCT07522463 — Enhancing Attention and Processing Speed Through Home-based Music Rehabilitation Program After Stroke in Malaysia · NA · not yet recruiting
NCT07341802 — Pilot Feasibility Study of a Fall Prevention Exercise Programme for Community-dwelling Older Adults in Nanchang, China · NA · recruiting
NCT07452705 — Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery. · NA · not yet recruiting
NCT07369596 — Impact of Chemotherapy Dose Reductions on Survival Outcomes Among Older NSCLC Patients Without Actionable Mutations · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05327348 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Malaya
Last refreshed: 25 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05327348.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing