NCT05326893

The Preventive Effects of Neurodynamic Mobilisation

Completed NA Last updated 4 November 2024

What this trial tests

NA trial testing Femoral nerve neurodynamic mobilization in Delayed Onset Muscle Soreness in 34 participants. Completed in 13 May 2022.

Timeline

20 February 2020

Primary endpoint
20 October 2020

13 May 2022

Quick facts

Lead sponsor	Uğur Sözlü
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	34
Start date	20 February 2020
Primary completion	20 October 2020
Estimated completion	13 May 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Femoral nerve neurodynamic mobilization
• Femoral nerve placebo neurodynamic mobilization

Conditions studied

• Delayed Onset Muscle Soreness — all drugs for Delayed Onset Muscle Soreness →

Sponsor

Uğur Sözlü

Who can join

Adults 18 to 32, male only, with Delayed Onset Muscle Soreness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the study, 34 healthy sedentary male volunteers were randomly divided into two groups as NM (n = 17) and SHAM-NM (n = 17). After the initial evaluation of the individuals, femoral nerve NM and placebo NM techniques were administered three sets a day with ten repetitions for three days a week for three weeks. Three days after the end of the applications, the second evaluations were made and the DOMS creation protocol for the quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30 sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed) were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72. During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH), and inflammation (interleukin-6 (IL-6), tumor necrosis factor-alpha) biomarkers, pain (activity), pressure pain threshold, and performance (one-leg jump, vertical jump) parameters were measured.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Preventive effect of the neurodynamic mobilization technique on delayed onset of muscle soreness: a randomized, single-blinded, placebo-controlled study.
   Sozlu U, Basar S, Semsi R, Akaras E, et al · · 2025 · cited 2× · PMID 40349018 · DOI 10.1186/s12891-025-08723-8