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NCT05322694
Clinical Decision Rules in the Emergency Department to Improve the Management of Acute Respiratory Infection and Acute Infectious Diarrhea
trial in Acute Respiratory Infection in 1,474 participants. Completed in 31 March 2023.
31 December 2022
Quick facts
| Lead sponsor | Simon Berthelot |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,474 |
| Start date | 3 February 2022 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 March 2023 |
| Sites | 3 locations across Canada |
Conditions studied
- Acute Respiratory Infection — all drugs for Acute Respiratory Infection →
- Acute Bacterial Diarrhea — all drugs for Acute Bacterial Diarrhea →
Sponsor
Simon Berthelot
Who can join
18 and older, any sex, with Acute Respiratory Infection or Acute Bacterial Diarrhea. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute respiratory infections (such as influenza-like illness and upper respiratory tract infection) and acute infectious diarrhea are, for the most part, conditions that do not require medical management or specific treatment. Depending on the level of their transmission in the community, however, these diseases place significant clinical and financial burden on the healthcare system, particularly on emergency departments (ED). The investigators propose a prospective multicenter cohort study with which they aim to validate clinical decision rules combining 1) rapid molecular tests and 2) risk stratification tools to identify patients at low risk for complications related to acute respiratory infection and acute infectious diarrhea. The use of these clinical decision rules by nurses in ED triage could allow low-risk patients to be sent directly home for self-treatment without having to see the emergency physician. By eliminating the need for physician assessment, paraclinical testing and prolonged waiting in the ED, these triage-based clinical decision rules could provide a new, safe care pathway for acute respiratory infections and acute infectious diarrhea, reducing the burden on the patient, the healthcare system, and society.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical presentation of Enterovirus D68 in adults with acute respiratory infections consulting in emergency departments in Quebec, Canada.
Mallet MC, Trottier S, Baz M, Redah I, et al · · 2025 · PMID 40575491 · DOI 10.1016/j.ijregi.2025.100669
Verify or expand the search:
- PubMed search for NCT05322694
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for Acute Respiratory Infection
Currently open trials in the same condition.
- NCT06271655 — Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Dep · NA · active not recruiting
- NCT06379542 — Efficacy and Safety of XC8, Film-coated Tablets, in Children With Acute Respiratory Viral Infections · Phase 3 · recruiting
- NCT05814237 — POS-ARI-ER Observational Study of Acute Respiratory Infections · recruiting
- NCT04099082 — Signature of the Host Response to a Respiratory Viral Infection, in the Prediction of Bronchiolitis Obliterans · recruiting
Other Simon Berthelot trials
Trials by the same sponsor.
- NCT05892666 — The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Managem · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05322694 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Simon Berthelot
- Last refreshed: 30 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05322694.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing