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NCT05320510
Effect of Selenium Supplementation on Glycemic Control in Patients With Type 2 Diabetes or Prediabetes
NA trial testing Se-yeast in Type 2 Diabetes in 130 participants. Status unknown.
1 January 2023
Quick facts
| Lead sponsor | Huazhong University of Science and Technology |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 130 |
| Start date | 1 October 2022 |
| Primary completion | 1 January 2023 |
| Estimated completion | 1 March 2023 |
Drugs / interventions tested
- Se-yeast
- Placebo
Conditions studied
- Type 2 Diabetes — all drugs for Type 2 Diabetes →
- PreDiabetes — all drugs for PreDiabetes →
Sponsor
Huazhong University of Science and Technology
Who can join
Adults 30 to 70, any sex, with Type 2 Diabetes or PreDiabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although it has been suggested that selenium (Se) increases the risk of T2DM, most evidence comes from observational studies that cannot prove causality. A systematic review assessed randomized clinical trials and found that the risk of T2DM was not greater in those randomized to Se supplementation than in those randomized to placebo. Se is a toxic element in animals and humans, and overexposure to Se has also been linked to detrimental health effects in humans. Previous studies were mostly conducted in Se-sufficient areas. Moreover, the effectiveness of low-dose Se supplementation on participants with elevated glycemic status was unknown. This cross-over, double blinded, randomized controlled trail aimed to investigate the effectiveness of Se supplementation for glucose control among participants with diabetes or prediabetes. Moreover, we also aimed to examine whether selenoprotein P genotypes, Se-related gut microbiota and their related metabolite modified the effectiveness.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Roles and Pathogenesis Mechanisms of a Number of Micronutrients in the Prevention and/or Treatment of Chronic Hepatitis, COVID-19 and Type-2 Diabetes Mellitus.
Sumaily KM. · · 2022 · cited 9× · PMID 35807813 · DOI 10.3390/nu14132632
Verify or expand the search:
- PubMed search for NCT05320510
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Huazhong University of Science and Technology trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05320510 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Huazhong University of Science and Technology
- Last refreshed: 6 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05320510.
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