Last reviewed · How we verify
NCT05320328: MBOP
RADIO FREQUENCY ABLATION IN UNRESECTABLE MALIGNANT BILIARY OBSTRUCTION
trial testing Radio frequency ablation in Bile Duct Neoplasms in 50 participants. Status unknown.
10 June 2022
Quick facts
| Lead sponsor | Asian Institute of Gastroenterology, India |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 10 June 2021 |
| Primary completion | 10 June 2022 |
| Estimated completion | 10 December 2022 |
| Sites | 1 location across India |
Drugs / interventions tested
- Radio frequency ablation
Conditions studied
- Bile Duct Neoplasms — all drugs for Bile Duct Neoplasms →
- Gall Bladder Carcinoma — all drugs for Gall Bladder Carcinoma →
Sponsor
Asian Institute of Gastroenterology, India
Who can join
Adults 18 to 75, any sex, with Bile Duct Neoplasms or Gall Bladder Carcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Endoscopic retrograde cholangio pancreatography procedure will performed as per local standard procedure.After common bile duct cannulation,cholangiography will be performed (to confirm the stricture) followed by biliary sphincterotomy. All biliary strictures(Bismuth Type I/II/III/IV) will be enrolled for the study. Patient opting for Uncovered self expandable metallic stent / Plastic stent will undergo biliary stent placement and considered under control arm Patient opting for radio frequency ablation + Uncovered SEMS/Plastic stent will undergo radio frequency ablation and biliary stent placement and considered under Study arm The RFA probe will be inserted into the bile duct alongwith the guidewire. Keeping the electrode overlapping the stricture, RFA will be performed using a power of 10W for 120 seconds. The electrode will be kept at the ablation site for an additional 1 minute to allow the RFA probe to cool before removal to prevent thermal injury of normal tissue and/or endoscope accessory channel. If the stricture is more than 3 cm, step-by-step RFA will be performed from the superior to inferior aspect. After RFA application, an uncovered SEMS/Plastic stent will be placed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adjuvant endobiliary radio-frequency ablation combined with self-expandable biliary metal stents for unresectable malignant hilar strictures: A pragmatic comparative study.
Jagtap N, Kumar CS, Lakhtakia S, Ramchandani M, et al · · 2025 · cited 2× · PMID 39240508 · DOI 10.1007/s12664-024-01668-1
Verify or expand the search:
- PubMed search for NCT05320328
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Radio frequency ablation
Trials testing the same drug.
- NCT06098989 — A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolati · NA · not yet recruiting
- NCT05243082 — Endoscopic Ultrasound Guided Radio Frequency Ablation of Pancreatic Neuroendocrine Neoplasms · NA · recruiting
- NCT04377594 — Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation. · NA · active not recruiting
Other recruiting trials for Bile Duct Neoplasms
Currently open trials in the same condition.
- NCT05286814 — PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Color · Phase 2 · recruiting
- NCT05172310 — PET Imaging of Solid Tumors by a Novel Tracer, 68Ga-FAPI · Phase 1 · recruiting
Other Asian Institute of Gastroenterology, India trials
Trials by the same sponsor.
- NCT07486518 — A Multicentre Prospective Cohort Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy An · not yet recruiting
- NCT07413822 — A Single-centre Open, Prospective, Pilot Clinical Study to Assess the Safety and Performance of the TIES® Transcutaneous · NA · not yet recruiting
- NCT07399652 — Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures · NA · recruiting
- NCT07371832 — A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colo · recruiting
- NCT07329816 — External, Multicentre Validation of a Machine-Learning Model to Predict Colonic Adenoma in Indian Adults · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05320328 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Asian Institute of Gastroenterology, India
- Last refreshed: 11 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05320328.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing