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NCT05318261: WIPO
Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational Study
trial testing Spontaneous breathing trial in Weaning Failure in 500 participants. Completed in 3 June 2022.
28 February 2021
Quick facts
| Lead sponsor | Bicetre Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 1 July 2019 |
| Primary completion | 28 February 2021 |
| Estimated completion | 3 June 2022 |
| Sites | 1 location across France |
Drugs / interventions tested
- Spontaneous breathing trial
Conditions studied
- Weaning Failure — all drugs for Weaning Failure →
- Weaning-induced Pulmonary Edema — all drugs for Weaning-induced Pulmonary Edema →
- Spontaneous Breathing Trial — all drugs for Spontaneous Breathing Trial →
Sponsor
Bicetre Hospital
Who can join
18 and older, any sex, with Weaning Failure or Weaning-induced Pulmonary Edema. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
During weaning from mechanical ventilation, the shift from positive to negative pressure ventilation may be responsible for a cardiac dysfunction that can lead to the development of pulmonary oedema (weaning-induced pulmonary oedema, WIPO) and to the failure of spontaneous breathing trials. However, the incidence and risk factors for WIPO development are not well defined and have been investigated only by a few studies.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Incidence and risk factors of weaning-induced pulmonary oedema: results from a multicentre, observational study.
Shi R, Ayed S, Beuzelin M, Persichini R, et al · · 2025 · cited 4× · PMID 40165223 · DOI 10.1186/s13054-025-05350-6
Verify or expand the search:
- PubMed search for NCT05318261
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Spontaneous breathing trial
Trials testing the same drug.
- NCT05226247 — Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study) · NA · unknown
Other recruiting trials for Weaning Failure
Currently open trials in the same condition.
- NCT07105202 — Shorter Weaning From Invasive Ventilation With Levosimendan · Phase 4 · recruiting
- NCT07003672 — Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostom · recruiting
- NCT06683781 — Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients · recruiting
- NCT06754670 — Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning · recruiting
- NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting
Other Bicetre Hospital trials
Trials by the same sponsor.
- NCT07453901 — The Multicentre Prospective Observational Study on the Management of Septic Shock · not yet recruiting
- NCT06772038 — Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion · recruiting
- NCT06839404 — Pharmacodynamic Analysis of the HaemOdynamic Effects of a Standard Fluid BolUS · recruiting
- NCT05676723 — Thoracic Fluid Content by Bioimpedance-based Starling System · completed
- NCT04870892 — Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05318261 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bicetre Hospital
- Last refreshed: 16 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05318261.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing