NCT05315271

Supraclavicular Brachial Plexus Block During Upper Limb Surgeries

Completed EARLY_PHASE1 Last updated 3 February 2023

What this trial tests

EARLY_PHASE1 trial testing Bupivacaine-ketamine injection in Brachial Plexus Block in 60 participants. Completed in 20 January 2023.

Timeline

1 June 2022

Primary endpoint
1 January 2023

20 January 2023

Quick facts

Lead sponsor	Sohag University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	screening
Enrollment	60
Start date	1 June 2022
Primary completion	1 January 2023
Estimated completion	20 January 2023
Sites	1 location across Egypt

Drugs / interventions tested

• Bupivacaine-ketamine injection — full drug profile →
• Bupivacaine injection with intravenous ketamine infusion — full drug profile →

Conditions studied

• Brachial Plexus Block — all drugs for Brachial Plexus Block →

Sponsor

Sohag University

Who can join

Adults 18 to 75, any sex, with Brachial Plexus Block. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Comparative Study Between Ketamine-Bupivacaine Versus Bupivacaine With Intravenous Ketamine Infusion In Supraclavicular Brachial Plexus Block During Upper limb Surgeries The techniques of regional anesthesia have become very popular as they provide several advantages in comparison with general anesthesia and systemic analgesia.

They provide perfect pain control, decreased complications and reduced post-anesthesia care unit stay.

Regional anesthesia provides more patient safety and better outcomes, which leads to the fact that ultrasound-guided regional anesthesia became more popular.

Ultrasound provides clinicians with real-time images which are useful for better identification of the anatomical structures, safe needle placement and adequate local anesthetic spread.

Brachial plexus blocks are commonly achieved via an interscalene, supraclavicular, infraclavicular or axillary approach.

The supraclavicular level is an ideal site to achieve anesthesia of the entire upper extremity just distal to the shoulder as the plexus remains relatively tightly packed at this level, resulting in a rapid and high-quality block. For this reason, the supraclavicular block is often called the ''spinal of the arm'' Using the local anesthetics alone for supraclavicular brachial plexus block provide good operative conditions but have the disadvantage of shorter duration of postoperative analgesia. Various adjuvants such as opioids, dexmedetomidine, dexamethasone, midazolam, ketamine, etc., were added to local anesthetics in brachial plexus block to achieve quick and prolonged block.

Ketamine is a noncompetitive antagonist of the N-methyl-D aspartate receptor(NMDAR).

It is used as a premedication, and for sedation, induction and maintenance of general anesthesia.

Local anesthetic and analgesic properties have been reported for ketamine. Intravenous administration of low-dose ketamine decreases postoperative opioid use and improves analgesia.

Ketamine has been added to bupivacaine to prolong the duration of regional anesthesia and postoperative analgesia.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.