Adults 21 to 28, any sex, with Executive Function. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Task Switch Test Response TimesPrimary· 30 minutes
The shifting aspect of executive function was assessed using a computerised task-switching test. Each participant (N=78) completed 384 trials across six blocks (64 trials per block). The test consisted of two types of cognitive tasks: (1) number magnitude judgment (greater/less than 5) for digits 1-9 presented in solid-line squares, and (2) odd/even judgment for numbers presented in dotted-line squares. Performance was analysed by calculating each participant's mean response time (milliseconds) under four conditions:
Homogeneous condition: Blocks where participants performed the same task rep
Heterogeneous
Group
Value
95% CI
Concurrent Exercise Group, CE
783.97
± 11.65
Aerobic Exercise Group, AE
788.76
± 11.66
Reading Control Group, RC
839.46
± 11.65
Homogeneous
Group
Value
95% CI
Concurrent Exercise Group, CE
566.46
± 14.67
Aerobic Exercise Group, AE
547.82
± 14.70
Reading Control Group, RC
618.30
± 14.72
Non-switch
Group
Value
95% CI
Concurrent Exercise Group, CE
737.73
± 11.63
Aerobic Exercise Group, AE
753.98
± 11.62
Reading Control Group, RC
797.48
± 11.62
Switch
Group
Value
95% CI
Concurrent Exercise Group, CE
833.32
± 13.34
Aerobic Exercise Group, AE
825.39
± 13.34
Reading Control Group, RC
882.18
± 13.34
Blood LactateSecondary· before intervention, 17 minutes after intervention, and immediately after the 35 minute intervention
The lactic acid system is one of the important systems of human energy metabolism. In addition to supplying energy to muscles, it can also be used as an energy source for brain energy metabolism. When people doing exercise, the concentration of blood lactate will be increased, and the lactate acid system will replace the glucose system as the main energy source for the brain. In the present study, blood lactate were collected from fingertip with a lancet and measured by lactate analyzer before, 17 minutes after, and after intervention.
Before intervention
Group
Value
95% CI
Concurrent Exercise Group, CE
2.95
± 0.32
Aerobic Exercise Group, AE
3.09
± 0.32
Reading Control Group, RC
2.4
± 0.32
Seventeen minutes after intervention
Group
Value
95% CI
Concurrent Exercise Group, CE
5.58
± 0.41
Aerobic Exercise Group, AE
5.27
± 0.41
Reading Control Group, RC
2.13
± 0.41
After intervention
Group
Value
95% CI
Concurrent Exercise Group, CE
8.94
± 0.44
Aerobic Exercise Group, AE
4.65
± 0.44
Reading Control Group, RC
2.44
± 0.44
Sponsor's own description
Executive function is a high-level cognition which plays an important role in our life. Meta-analysis study has demonstrated that acute exercise could improve executive function. However, it is still unclear whether executive function can be enhanced by the concurrent exercise that combines aerobic and resistance exercise. Moreover, previous studies indicated that acute exercise could increase the concentration of blood lactate which is positive correlated to executive function. It is still unclear whether the effect of acute concurrent exercise on executive function is mediated by blood lactate. Therefore, the purposes of present study are: (1) Measuring the effect of acute concurrent exercise and aerobic exercise on executive function. (2) Measuring whether the effect of acute concurrent exercise on executive function is mediated by blood lactate.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Sponsor: as reported to ClinicalTrials.gov by National Taiwan Normal University
Last refreshed: 20 February 2025
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