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Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section: A Randomized Clinical Trial
Cardiac disease in pregnancy is a high-risk condition and a major cause of maternal mortality and morbidity. Although direct or immediate death due to cardiovascular disease is rare, it is an important indirect cause of maternal death worldwide, with an attributable rate of two deaths per 100,000 pregnancies. Cardiovascular physiological changes during pregnancy impose an additional load on the cardiovascular system of women with underlying heart disease which increases morbidity and mortality during pregnancy and at the time of delivery. Among cardiac diseases, Rheumatic Heart Disease is the commonest cardiac disease complicating pregnancy.
Details
| Lead sponsor | Assiut University |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | UNKNOWN |
| Enrolment | 102 |
| Start date | 2022-04 |
| Completion | 2022-12 |
Conditions
- Granisetron
Interventions
- Granisetron Hydrochloride
- 0.9% normal saline
Primary outcomes
- post-spinal hypotension, and bradycardia — 24 hours postoperative
post-spinal hypotension, and bradycardia in rheumatic patients undergoing elective cesarean section
Countries
Egypt