Last reviewed · How we verify
Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain
Cancer pain is one of the most common and problematic symptoms. Opioids are typically the most common drugs used in the treatment of cancer pain,they are limited due to their side effects. Tramadol is a centrally acting non-opiate analgesic with low affinity for μ-opioid receptors, and is effective in the treatment of moderate to severe pain. Neuropathic pain is typically not amenable to standard opiate therapy, and the addition of tricyclic antidepressants or/and antiepileptic drugs can offer a very effective treatment strategy in such patients. Duloxetine is a Serotonin Norepinephrine Reuptake Inhibitor (SNRI) that has been used traditionally for its antidepressant qualities and has also analgesic benefit in the treatment of neuropathic pain. Duloxetine exerts its analgesic action through central and peripheral pain modulation .
Details
| Lead sponsor | Assiut University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 400 |
| Start date | Fri Apr 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Oct 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Cancer Pain
Interventions
- Duloxetine 30 mg
- Tramadol
- Placebo
Countries
Egypt