Last reviewed · How we verify
NCT05310552: GO-DS21
Elucidating Age-related Comorbidity Patterns in Down Syndrome (DS)
trial testing No interventions - observational study in Down Syndrome in 230 participants. Completed in 30 June 2025.
30 November 2024
Quick facts
| Lead sponsor | King's College London |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 230 |
| Start date | 10 June 2021 |
| Primary completion | 30 November 2024 |
| Estimated completion | 30 June 2025 |
| Sites | 3 locations across France, United Kingdom, Spain |
Drugs / interventions tested
- No interventions - observational study
Conditions studied
- Down Syndrome — all drugs for Down Syndrome →
Sponsor
King's College London
Who can join
Adults 12 to 45, any sex, with Down Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is a non-drug, multicenter, prospective cohort study. It will be conducted in 300 volunteers from 12 to 45 years of age (inclusive) with a diagnosis of Down syndrome from 3 countries (France, Spain, United Kingdom (UK)). The basic hypotheses of the study are the following: 1. Diseases (and comorbidity) arise from one or more biological networks perturbed by the genetic disorder (trisomy 21) through interaction with environmental risks factors and epigenetic changes. 2. Health comorbidity patterns in DS individuals (particularly of obesity and related conditions) will likely vary by age and sex. 3. Obesity comorbidity patterns will relate to variation in factors including lifestyle, stress-response, severity of intellectual disability (ID) and variation in cognitive domains such as executive functioning. 4. Stress responses, as measured with cortisol concentrations, will differentiate individuals with DS who are obese and those who are not. Extremes in phenotype (Obese vs. Non-obese) will be related to differences in the metabolomic, transcriptomic, and microbiome concentrations.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dietary Patterns and Lifestyle Factors as Determinants of Body Mass Index and Body Composition in Individuals with Down Syndrome-A Study Across Three Clinical Sites.
Gomis-González M, Boronat A, Langohr K, Bianchi LA, et al · · 2026 · PMID 41829952 · DOI 10.3390/nu18050779
Verify or expand the search:
- PubMed search for NCT05310552
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Down Syndrome
Currently open trials in the same condition.
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Other King's College London trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05310552 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King's College London
- Last refreshed: 9 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05310552.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing