Who is sponsoring NCT05309655?

NCT05309655 is sponsored by Duke University.

What drugs are being tested in NCT05309655?

Interventions in NCT05309655: Adenosine Stress Cardiac Magnetic Resonance Imaging, Electrocardiogram, Computed Tomography Angiogram, Laboratory Testing, Quality of Life Survey.

What condition does NCT05309655 study?

NCT05309655 studies Breast Cancer, Triple Negative Breast Cancer, Cardiovascular Complications.

Is NCT05309655 still recruiting?

NCT05309655 is currently recruiting now. Last updated 16 March 2026.

Last reviewed 2026-03-16 · How we verify

NCT05309655: CROWN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cardiac Outcomes With Near-Complete Estrogen Deprivation

Recruiting now NA Last updated 16 March 2026

What this trial tests

NA trial testing Adenosine Stress Cardiac Magnetic Resonance Imaging in Breast Cancer in 90 participants. Currently enrolling.

Timeline

2 September 2022

Primary endpoint
1 May 2028

1 December 2028

Quick facts

Lead sponsor	Duke University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	90
Start date	2 September 2022
Primary completion	1 May 2028
Estimated completion	1 December 2028
Sites	3 locations across United States

Drugs / interventions tested

Adenosine Stress Cardiac Magnetic Resonance Imaging — full drug profile →
Electrocardiogram
Computed Tomography Angiogram
Laboratory Testing
Quality of Life Survey

Conditions studied

Breast Cancer — all drugs for Breast Cancer →
Triple Negative Breast Cancer — all drugs for Triple Negative Breast Cancer →
Cardiovascular Complications — all drugs for Cardiovascular Complications →

Sponsor

Duke University

Who can join

Adults 18 to 55, female only, with Breast Cancer or Triple Negative Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this research study is to understand what effect near complete estrogen deprivation (NCED) therapy has on the heart in breast cancer patients. Investigators want to understand if NCED changes how the heart works.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Cardiovascular impact of near complete estrogen deprivation in premenopausal women with breast cancer: The CROWN study.
Thomas A, O'Connell NS, Douglas E, Hatcher S, et al · · 2024 · cited 1× · PMID 37890547 · DOI 10.1016/j.ahj.2023.10.007

Verify or expand the search:

Other recruiting trials for Breast Cancer

Currently open trials in the same condition.

NCT06148038 — CBD for Breast Cancer Primary Tumors · Phase 1 · recruiting
NCT07405801 — A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus R · Phase 2 · recruiting
NCT07285993 — Detection and Outcomes in Metastatic Invasive Lobular Breast Cancer Through Novel F-18 FAP PET · Phase 2 · recruiting
NCT07510698 — Same-Day Awake Mastectomy With Immediate Breast Reconstruction for Patients With Breast Cancer · NA · recruiting
NCT06768931 — Biolosion Combined Standard Neoadjuvant Therapy to Treat Triple-negative Breast Cancer · Phase 2 · recruiting

Other Duke University trials

Trials by the same sponsor.

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NCT07459218 — IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05309655 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Duke University
Last refreshed: 16 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05309655.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing