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Peritoneal Diffusion and Efficacy of Antibiotic Therapy in Pediatric Peritonitis (DIFFUPERPED)
This is a pilote monocentric prospective study about pediatric peritonitis and antibiotics pharmacokinetic and pharmacodynamic. The investigators will include 41 patients between 3 and 17 years-old during 2 years in the University Hospital of Nancy. The aim of this study is to determine if the beta-lactam dosages in children recommended by the guidelines for management of intra-abdominal infections permitted the achievement of adequatly serum and peritoneal concentrations in the medical and surgical management of peritonitis. The investigators will collected serum and peritoneal fluid samples at 3 different times: peritoneal incision, end of surgery, 2 days and 5 days after surgery in order to compare the concentrations and the minimal inhibitor concentration of bacteria. The hypothesis is that of a serum and peritoneal antibiotic under dosage.
Details
| Lead sponsor | Central Hospital, Nancy, France |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 41 |
| Start date | Thu Mar 31 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sun Jun 30 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Peritonitis
- Appendicitis
- Children, Only
- Antibiotic Toxicity
Interventions
- Dosage of serum and peritoneal of the betalactam used for antibiotic treatment