NCT05307575 (NAUTILUS) is a clinical trial in Post-COVID Syndrome, sponsored by Consorci Sanitari de Terrassa.

Who is sponsoring NCT05307575?

NCT05307575 is sponsored by Consorci Sanitari de Terrassa.

What condition does NCT05307575 study?

NCT05307575 studies Post-COVID Syndrome.

Is NCT05307575 still recruiting?

NCT05307575 is currently completed. Last updated 19 September 2024.

Last reviewed 2024-09-19 · How we verify

NCT05307575: NAUTILUS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neurobehavior and Brain Connectivity in Post COVID-19 Patients

Completed Last updated 19 September 2024

What this trial tests

trial in Post-COVID Syndrome in 630 participants. Completed in 15 September 2024.

Timeline

1 October 2021

Primary endpoint
15 September 2024

15 September 2024

Quick facts

Lead sponsor	Consorci Sanitari de Terrassa
Status	Completed
Study type	OBSERVATIONAL
Enrollment	630
Start date	1 October 2021
Primary completion	15 September 2024
Estimated completion	15 September 2024
Sites	1 location across Spain

Conditions studied

Post-COVID Syndrome — all drugs for Post-COVID Syndrome →

Sponsor

Consorci Sanitari de Terrassa — full company profile →

Who can join

Adults 18 to 65, any sex, with Post-COVID Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

COVID-19 neurological effects can generate long-term neurobehavioral dysfunction. Our main objective is to examine the impact of COVID-19 on neurobehavior and its relationship with illness severity. Besides, we aim to study structural and functional brain connectivity in a subsample of middle-aged post-COVID-19 individuals. Finally, we aim to develop predictive models of neurobehavioural evolution in post-COVID-19 based on multimodal data.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Neuropsychological impairment in post-COVID condition individuals with and without cognitive complaints.
Ariza M, Cano N, Segura B, Adan A, et al · · 2022 · cited 64× · PMID 36337708 · DOI 10.3389/fnagi.2022.1029842
COVID-19 severity is related to poor executive function in people with post-COVID conditions.
Ariza M, Cano N, Segura B, Adan A, et al · · 2023 · cited 40× · PMID 36939932 · DOI 10.1007/s00415-023-11587-4
Cognitive and emotional predictors of quality of life and functioning after COVID-19.
Ariza M, Cano N, Segura B, Bejar J, et al · · 2024 · cited 13× · PMID 38130039 · DOI 10.1002/acn3.51952
Structural brain changes in post-COVID condition and its relationship with cognitive impairment.
Pacheco-Jaime L, Garcia-Vicente C, Ariza M, Cano N, et al · · 2025 · cited 12× · PMID 40008326 · DOI 10.1093/braincomms/fcaf070
Sleep quality in individuals with post-COVID-19 condition: Relation with emotional, cognitive and functional variables.
Carnes-Vendrell A, Piñol-Ripoll G, Ariza M, Cano N, et al · · 2024 · cited 12× · PMID 38269302 · DOI 10.1016/j.bbih.2023.100721
Eye movements in patients with post-COVID condition.
Vinuela-Navarro V, Goset J, Aldaba M, Mestre C, et al · · 2023 · cited 5× · PMID 37799689 · DOI 10.1364/boe.489037
Functional brain abnormalities in post COVID-19 condition and their relationship with cognition.
Carreras-Vidal L, Pacheco-Jaime L, Ariza M, Cano N, et al · · 2025 · cited 4× · PMID 40595626 · DOI 10.1038/s41598-025-00739-3
Cognitive reserve, depressive symptoms, obesity, and change in employment status predict mental processing speed and executive function after COVID-19.
Ariza M, Béjar J, Barrué C, Cano N, et al · · 2025 · cited 4× · PMID 38285245 · DOI 10.1007/s00406-023-01748-x

Verify or expand the search:

Other Consorci Sanitari de Terrassa trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05307575 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Consorci Sanitari de Terrassa
Last refreshed: 19 September 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05307575.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing