NCT05306665 (PREPS) is a NA clinical trial of ACT intervention in Pain, Back, sponsored by Brigham and Women's Hospital.

Who is sponsoring NCT05306665?

NCT05306665 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT05306665?

Interventions in NCT05306665: ACT intervention.

What condition does NCT05306665 study?

NCT05306665 studies Pain, Back, Spinal Stenosis, Disc Herniation, Spondylosis, Spondylolisthesis, Back Injuries.

Is NCT05306665 still recruiting?

NCT05306665 is currently recruiting now. Last updated 28 October 2024.

Last reviewed 2024-10-28 · How we verify

NCT05306665: PREPS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PREventing Pain After Surgery

Recruiting now NA Last updated 28 October 2024

What this trial tests

NA trial testing ACT intervention in Pain, Back in 140 participants. Currently enrolling.

Timeline

13 January 2023

Primary endpoint
1 August 2026

1 August 2026

Quick facts

Lead sponsor	Brigham and Women's Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	140
Start date	13 January 2023
Primary completion	1 August 2026
Estimated completion	1 August 2026
Sites	1 location across United States

Drugs / interventions tested

ACT intervention

Conditions studied

Pain, Back — all drugs for Pain, Back →
Spinal Stenosis — all drugs for Spinal Stenosis →
Disc Herniation — all drugs for Disc Herniation →
Spondylosis — all drugs for Spondylosis →

Sponsor

Brigham and Women's Hospital

Who can join

22 and older, any sex, with Pain, Back or Spinal Stenosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present study aims to adapt and modify a brief presurgical Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use. Investigators will then assess the acceptability, feasibility, and preliminary efficacy of the finalized intervention to prevent the transition to CPSP and reduce post-surgical opioid use six months following lumbar spine surgery. Finally, investigators will identify psychosocial and psychophysical phenotypes associated with response to this intervention.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A one-day acceptance and commitment therapy workshop for the prevention of chronic post-surgical pain and long-term opioid use following spine surgery: Protocol for a pilot feasibility randomized controlled trial.
Yamin JB, Pester BD, Kommu R, Allen C, et al · · 2025 · PMID 39719249 · DOI 10.1016/j.cct.2024.107785

Verify or expand the search:

Other recruiting trials for Pain, Back

Currently open trials in the same condition.

NCT06415461 — A Study Assessing the Safety of Cord Blood Product in Sacroiliac Joint Syndrome (SIJ) · Phase 1 · active not recruiting
NCT05461092 — Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion · EARLY_PHASE1 · recruiting
NCT05626049 — Implementation of the ACP Guideline for Low Back Pain (IMPACt-LBP) · NA · active not recruiting
NCT05058287 — Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression · Phase 3 · recruiting
NCT05463367 — Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure · Phase 2 · active not recruiting

Other Brigham and Women's Hospital trials

Trials by the same sponsor.

NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05306665 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 28 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05306665.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing