NCT05306379 (Statin-DDI) is a Phase 1 clinical trial of Simvastatin in Drug-drug Interaction, sponsored by Aurinia Pharmaceuticals Inc..

Who is sponsoring NCT05306379?

NCT05306379 is sponsored by Aurinia Pharmaceuticals Inc..

What drugs are being tested in NCT05306379?

Interventions in NCT05306379: Simvastatin, Voclosporin.

What condition does NCT05306379 study?

NCT05306379 studies Drug-drug Interaction.

Is NCT05306379 still recruiting?

NCT05306379 is currently completed. Last updated 20 April 2022.

Last reviewed 2022-04-20 · How we verify

NCT05306379: Statin-DDI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin

Completed Phase 1 Last updated 20 April 2022

What this trial tests

Phase 1 trial testing Simvastatin in Drug-drug Interaction in 24 participants. Completed in 5 April 2022.

Timeline

24 January 2022

Primary endpoint
5 April 2022

5 April 2022

Quick facts

Lead sponsor	Aurinia Pharmaceuticals Inc.
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	24
Start date	24 January 2022
Primary completion	5 April 2022
Estimated completion	5 April 2022
Sites	1 location across United States

Drugs / interventions tested

Simvastatin (simvastatin) — full drug profile →
Voclosporin — full drug profile →

Conditions studied

Drug-drug Interaction — all drugs for Drug-drug Interaction →

Sponsor

Aurinia Pharmaceuticals Inc. — full company profile →

Who can join

Adults 18 to 55, any sex, with Drug-drug Interaction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A single-center, open-label, Phase 1, drug-drug interaction study to investigate the effect of voclosporin on the pharmacokinetics of simvastatin and simvastatin acid in healthy volunteers.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Simvastatin

Trials testing the same drug.

NCT07102979 — Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbio · NA · enrolling by invitation
NCT06948747 — A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of E · Phase 1 · completed
NCT06858332 — Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia · recruiting
NCT07031778 — Topic Simvastatin for Bone Regeneration · EARLY_PHASE1 · recruiting
NCT06399783 — Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia Areata · Phase 4 · not yet recruiting

Other recruiting trials for Drug-drug Interaction

Currently open trials in the same condition.

NCT06381375 — Drug-drug Interactions With Anti-tuberculous Drugs · recruiting
NCT06682325 — Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients · recruiting
NCT05044962 — Kuwa Free! - Live Free! · NA · recruiting

Other Aurinia Pharmaceuticals Inc. trials

Trials by the same sponsor.

NCT05962788 — Long-Term Voclosporin Treatment in Adolescent and Pediatric Subjects With Lupus Nephritis · Phase 3 · terminated
NCT05288855 — Voclosporin in Adolescent and Pediatric Subjects With Lupus Nephritis · Phase 3 · terminated
NCT05337124 — A Prospective Observational Registry of Patients Treated With LUPKYNIS® (Voclosporin) in the US · completed
NCT04147650 — Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrom · Phase 2, PHASE3 · completed
NCT03597464 — Aurinia Renal Assessments 2: Aurinia Renal Response in Lupus With Voclosporin · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05306379 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aurinia Pharmaceuticals Inc.
Last refreshed: 20 April 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05306379.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing