NCT05304559

Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture

Status unknown NA Last updated 31 March 2022

What this trial tests

NA trial testing S-Ketamine in Hip Fractures in 108 participants. Status unknown.

Timeline

26 March 2022

Primary endpoint
26 April 2022

31 January 2023

Quick facts

Lead sponsor	Yangzhou University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	108
Start date	26 March 2022
Primary completion	26 April 2022
Estimated completion	31 January 2023
Sites	1 location across China

Drugs / interventions tested

• S-Ketamine
• Continuous iliac fascia space block
• Normal saline

Conditions studied

• Hip Fractures — all drugs for Hip Fractures →

Sponsor

Yangzhou University

Who can join

Adults 65 to 85, any sex, with Hip Fractures. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Elderly patients with hip fracture are older and have a high incidence of perioperative complications. the postoperative recovery of elderly patients with hip fracture is affected by hemodynamic instability and pain caused by fracture. S-ketamine is the S-isomer of ketamine. Compared with traditional ketamine, S-ketamine has stronger analgesic effect and fewer adverse reactions of nervous system. The parasympathetic effect of S-ketamine can antagonize the circulatory inhibition of propofol and make the hemodynamics more stable in elderly patients with hip fracture.Iliac fascial space block (fasciailiacacompartmentblock,FICB) mainly depends on local anesthetics spreading to the femoral nerve, lateral femoral cutaneous nerve and obturator nerve in the iliofascial space to achieve analgesia in its dominant area. Ultrasound-guided iliac fascial space block can effectively reduce the amount of anesthetics and has shorter puncture time and fewer complications. It can more effectively reduce the perioperative pain of elderly patients with hip fracture.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effect of intraoperative intravenous esketamine on postoperative delirium in older patients undergoing hip fracture surgery: protocol for a randomised, double-blind, placebo-controlled trial.
   Shao C, Huang Q, Huang W, Lu Y, et al · · 2025 · PMID 40054869 · DOI 10.1136/bmjopen-2024-092159