Last reviewed · How we verify
NCT05300971
Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults
NA trial testing Heat therapy in Aging in 150 participants. Currently enrolling.
1 November 2027
Quick facts
| Lead sponsor | University of Colorado, Boulder |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 150 |
| Start date | 1 August 2022 |
| Primary completion | 1 November 2027 |
| Estimated completion | 1 February 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Heat therapy
- Thermoneutral water immersion
Conditions studied
- Aging — all drugs for Aging →
Sponsor
University of Colorado, Boulder
Who can join
40 and older, any sex, with Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to determine the effects of \~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults. The study also aims to determine the effects of \~12 weeks of heat therapy on fluid cognitive and cerebrovascular function.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions.
Murray KO, Mahoney SA, Venkatasubramanian R, Seals DR, et al · · 2023 · cited 32× · PMID 36731386 · DOI 10.1016/j.exger.2023.112105 -
Promoting healthy cardiovascular aging: emerging topics.
Clayton ZS, Craighead DH, Darvish S, Coppock M, et al · · 2022 · cited 19× · PMID 36337728 · DOI 10.20517/jca.2022.27 -
Sex Differences in Dementia and Mild Cognitive Impairment in Nondialysis CKD.
Oh ES, Opoku G, Darvish S, Craighead DH, et al · · 2026 · PMID 41264372 · DOI 10.2215/cjn.0000000922
Verify or expand the search:
- PubMed search for NCT05300971
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Heat therapy
Trials testing the same drug.
- NCT06596967 — Heat Therapy in Type 2 Diabetes · Phase 1 · recruiting
- NCT05680493 — Comparison of Dry Needling and Manual Pressure Release for Managing Low Back Pain · NA · unknown
- NCT04778631 — Impact of Thermotherapy During Childbirth on Postpartum Perineal Pain (PERISAFE) · NA · completed
- NCT07158047 — Repeated Far Infrared Sauna Bathing in Adults With Obesity · NA · recruiting
- NCT04588103 — Artery Function Responses to Heat Therapy and Exercise Training · NA · completed
Other recruiting trials for Aging
Currently open trials in the same condition.
- NCT02831335 — Technical Development of Multi-Parametric Renocerebral MRI · recruiting
- NCT07099053 — Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging · recruiting
- NCT07504068 — Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in · NA · recruiting
- NCT07525453 — Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults · NA · recruiting
- NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting
Other University of Colorado, Boulder trials
Trials by the same sponsor.
- NCT07527338 — Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use · Phase 2, PHASE3 · not yet recruiting
- NCT07011160 — Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults · NA · not yet recruiting
- NCT07127965 — Exercise Adherence and Cognitive Decline: Phase 2 · NA · recruiting
- NCT06588582 — Perceptual Influences From Smoking Cannabis: an Experimental Study · NA · recruiting
- NCT06769022 — Exercise Adherence and Cognitive Decline · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05300971 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Boulder
- Last refreshed: 29 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05300971.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing