Last reviewed · How we verify
NCT05300737: SCORE
Symptomatic Carotid Outcomes Registry With Multi-center Evaluation
trial testing intensive medical therapy in Carotid Stenosis in 114 participants. Participants enrolled and being followed up; not accepting new ones.
1 December 2026
Quick facts
| Lead sponsor | University of Maryland, Baltimore |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 114 |
| Start date | 1 August 2022 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 18 locations across United States, Canada |
Drugs / interventions tested
- intensive medical therapy
Conditions studied
- Carotid Stenosis — all drugs for Carotid Stenosis →
- Ischemic Stroke — all drugs for Ischemic Stroke →
- Transient Ischemic Attack — all drugs for Transient Ischemic Attack →
Sponsor
University of Maryland, Baltimore
Who can join
40 and older, any sex, with Carotid Stenosis or Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Ischemic stroke
Time frame: within 12 months
ipsilateral to carotid stenosis, with radiologic confirmation
Sponsor's own description
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which creates a gap in knowledge. The aim of this study is to evaluate that clinical care with Intensive Medical Therapy (IMT) alone, the one year stroke rate in patients with symptomatic carotid stenosis and low risk clinical features will be \<5%.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05300737
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Carotid Stenosis
Currently open trials in the same condition.
- NCT07412249 — Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis · NA · recruiting
- NCT07057297 — Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study · recruiting
- NCT06546761 — Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial) · recruiting
- NCT06986330 — Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT） · active not recruiting
- NCT06485102 — Differences of the Postoperative Outcome for Carotid Surgery Patients Treated by Either Male or Female Surgeons · active not recruiting
Other University of Maryland, Baltimore trials
Trials by the same sponsor.
- NCT07537413 — Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia · Phase 4 · not yet recruiting
- NCT07221799 — OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis · Phase 1 · not yet recruiting
- NCT07094672 — Development of an Opioid Withdrawal Clinical Outcome Assessment · not yet recruiting
- NCT06583239 — Hub-Based Engagement Navigator Service to Reduce CSC Disengagement · NA · not yet recruiting
- NCT07536412 — Decision Aid Efficacy in Low Risk Thyroid Cancer · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05300737 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Maryland, Baltimore
- Last refreshed: 15 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05300737.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing