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Vascular Aging and Lp299v Study
Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascular risk factors or cardiovascular disease. Early human data suggest an increase in potentially pathological gut metabolites such as trimethylamine-N-oxide (TMAO) are associated with older age, increased vascular stiffness, increased oxidative stress, and reduced nitric oxide (NO) bioavailability as evidenced by impaired endothelium-dependent vasodilation. Based on this data, the investigators hypothesize that supplementation with Lp299v will reverse human vascular aging in healthy older adults free of known traditional cardiovascular risk factors.
Details
| Lead sponsor | Medical College of Wisconsin |
|---|---|
| Phase | NA |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 20 |
| Start date | Wed Feb 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Sep 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Vascular Aging
Interventions
- Lactobacillus Plantarum 299v in fermented oat drink
- Heat-Killed Placebo control fermented drink
Countries
United States