NCT05296109

Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation

Recruiting now NA Last updated 3 April 2026

What this trial tests

NA trial testing Magnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS) in Parotid Neoplasms in 50 participants. Currently enrolling.

Timeline

1 February 2022

Primary endpoint
30 June 2027

30 June 2027

Quick facts

Lead sponsor	Chinese University of Hong Kong
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	50
Start date	1 February 2022
Primary completion	30 June 2027
Estimated completion	30 June 2027
Sites	1 location across Hong Kong

Drugs / interventions tested

• Magnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS)

Conditions studied

• Parotid Neoplasms — all drugs for Parotid Neoplasms →

Sponsor

Chinese University of Hong Kong

Who can join

18 and older, any sex, with Parotid Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms. Within the parotid gland there are branches of the intra-parotid facial nerves, which are tiny in calibre and are prone to injury to injury during operation. It has been reported in recent retrospective view that the incidence of temporary and permanent facial nerve injury were 9.2% and 5.2% respectively, the risk of which increased with old age, malignant tumour and revision surgery. Traditional the incidental of facial nerve injury is reduced by intra-operative facial nerve monitoring and surgical magnification, while imaging has limited role in aiding this purpose. However with advancement in MRI technique high resolution three-dimensional sequences (i.e. neurogram sequences) are available for better visualization of branches of facial nerves. The investigators would therefore aim to demonstrate additional efficacy of these techniques and also to compare with conventional 3D post-contrast anatomical imaging studies in the localization and visualization of the facial nerve branches in patients with tumour. With better pre-operative imaging, the investigators hope to reduce the chance of facial nerve injury in these patients.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.