NCT05294497 is a NA clinical trial of Product A in Smoking, sponsored by RAI Services Company.

Who is sponsoring NCT05294497?

NCT05294497 is sponsored by RAI Services Company.

What drugs are being tested in NCT05294497?

Interventions in NCT05294497: Product A, Product B, Product C, Product D, Product N, Product E.

What condition does NCT05294497 study?

NCT05294497 studies Smoking, Tobacco Use, Tobacco Smoking.

Is NCT05294497 still recruiting?

NCT05294497 is currently completed. Last updated 29 June 2022.

Last reviewed 2022-06-29 · How we verify

NCT05294497

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

Completed NA Last updated 29 June 2022

What this trial tests

NA trial testing Product A in Smoking in 42 participants. Completed in 27 May 2022.

Timeline

1 May 2022

Primary endpoint
27 May 2022

27 May 2022

Quick facts

Lead sponsor	RAI Services Company
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	42
Start date	1 May 2022
Primary completion	27 May 2022
Estimated completion	27 May 2022
Sites	2 locations across United States

Drugs / interventions tested

Product A — full drug profile →
Product B — full drug profile →
Product C
Product D
Product N
Product E

Conditions studied

Smoking — all drugs for Smoking →
Tobacco Use — all drugs for Tobacco Use →
Tobacco Smoking — all drugs for Tobacco Smoking →

Sponsor

RAI Services Company

Who can join

Adults 21 to 60, any sex, with Smoking or Tobacco Use. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a two-site, open-label, randomized, 6-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics \[PD\]) and plasma nicotine uptake (pharmacokinetics \[PK\]) during and following ad libitum use of the study investigational products (IPs) by generally healthy smokers.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Randomized crossover clinical studies to assess abuse liability and nicotine pharmacokinetics of Velo Oral Nicotine pouches.
Kanobe MN, Powell CY, Patrudu M, Baxter SA, et al · · 2025 · cited 2× · PMID 40183092 · DOI 10.3389/fphar.2025.1547073

Verify or expand the search:

Other trials of Product A

Trials testing the same drug.

NCT07323563 — A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems · NA · not yet recruiting
NCT07323511 — Abuse Liability for Eight Electronic Nicotine Products · NA · not yet recruiting
NCT07132814 — Abuse Liability for Five Modern Oral Nicotine Products · NA · recruiting
NCT06777784 — Modern Nicotine Oral Product Abuse Liability · NA · completed
NCT06356610 — Pharmacokinetic and Subjective Effects of Heated Tobacco Products · NA · completed

Other recruiting trials for Smoking

Currently open trials in the same condition.

NCT07488741 — Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction · NA · recruiting
NCT07443631 — Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants · NA · recruiting
NCT07132814 — Abuse Liability for Five Modern Oral Nicotine Products · NA · recruiting
NCT06966258 — Inspire HER: Inspiring the Heart and Emotions for Radical Health · NA · recruiting
NCT06713603 — Technology Assisted Motivational Interviewing · NA · recruiting

Other RAI Services Company trials

Trials by the same sponsor.

NCT07323563 — A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems · NA · not yet recruiting
NCT07323511 — Abuse Liability for Eight Electronic Nicotine Products · NA · not yet recruiting
NCT07132814 — Abuse Liability for Five Modern Oral Nicotine Products · NA · recruiting
NCT07172438 — A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers · NA · terminated
NCT07175987 — A Consumer Use Behavior Study to Evaluate Puffing Topography and Average Daily Consumption of Heated Tobacco Products · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05294497 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by RAI Services Company
Last refreshed: 29 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05294497.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing