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NCT05291715
The Effect of Ozone Therapy on Pain Perception After Free Gingival Graft Surgery in Patients With Mucogingival Defects
NA trial testing Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C) in Open Wound of Palate Without Complication in 20 participants. Completed in 25 December 2022.
15 December 2022
Quick facts
| Lead sponsor | Omaima Mossad Mahmoud AL-Sherbini |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 15 June 2022 |
| Primary completion | 15 December 2022 |
| Estimated completion | 25 December 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C)
Conditions studied
- Open Wound of Palate Without Complication — all drugs for Open Wound of Palate Without Complication →
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Free Gingival Grafts — all drugs for Free Gingival Grafts →
- Mucogingival Defects — all drugs for Mucogingival Defects →
Sponsor
Omaima Mossad Mahmoud AL-Sherbini
Who can join
Adults 18 to 50, any sex, with Open Wound of Palate Without Complication or Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Gaseous ozone (O3-triatomic oxygen) is the third-strongest oxidizing agent worldwide. It influences the cellular and the humoral immune system, by stimulating the proliferation of immunocompetent cells and the synthesis of immunoglobulin. Additionally; biologically active substances, such as interleukins, leukotrienes and prostaglandins which are beneficial in reducing inflammation and wound healing are orchestrated following ozone application. Given that after harvesting of a free gingival graft from the palatal donor site, healing occurs by secondary intention process; for patients with mucogingival conditions. The investigators will compare the natural process of healing at the donor site versus the healing process consecutive to ozone application; with the primary outcome is to evaluate the postoperative pain perception using visual analogue scale and to estimate the consumption of analgesics tablets after surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Ozone in Chemotherapy-Induced Peripheral Neuropathy-Current State of Art, Possibilities, and Perspectives.
Szklener K, Rudzińska A, Juchaniuk P, Kabała Z, et al · · 2023 · cited 8× · PMID 36982352 · DOI 10.3390/ijms24065279
Verify or expand the search:
- PubMed search for NCT05291715
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05291715 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Omaima Mossad Mahmoud AL-Sherbini
- Last refreshed: 14 February 2023
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